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Insulin resistance and vitamin D deficiency in patients with chronic kidney disease stage 2-3.

Department of Clinical and Experimental Pharmacotherapy, Slovak Medical University, Bratislava, Slovakia.
Physiological research / Academia Scientiarum Bohemoslovaca (Impact Factor: 1.49). 10/2010; 60(1):149-55.
Source: PubMed

ABSTRACT Vitamin D status and the relationship between serum 25(OH) vitamin D concentrations and the components of insulin resistance were examined in 120 patients with chronic kidney disease stage 2 and 3. Insulin sensitivity/resistance was calculated by the quantitative insulin sensitivity check index (QUICKI). In this analysis, the prevalence of insulin resistance was 42 %. Only 17 % of patients had serum 25(OH) vitamin D concentration in the recommended range (>/=30 ng/ml), 42 % suffered from vitamin D insufficiency and 41 % had moderate vitamin D deficiency. Insulin resistance significantly correlated with serum 25(OH)D and 1,25(OH)(2)D concentrations, renal function and protein excretion rate. Our results support the increasing evidence that vitamin D deficiency may be one of the factors participating in the development of insulin resistance already in the early stages of chronic kidney disease.

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