Cancer Pharmacogenomics and Pharmacoepidemiology: Setting a Research Agenda to Accelerate Translation

National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7393, USA.
Journal of the National Cancer Institute (Impact Factor: 12.58). 10/2010; 102(22):1698-705. DOI: 10.1093/jnci/djq390
Source: PubMed


Recent advances in genomic research have demonstrated a substantial role for genomic factors in predicting response to cancer therapies. Researchers in the fields of cancer pharmacogenomics and pharmacoepidemiology seek to understand why individuals respond differently to drug therapy, in terms of both adverse effects and treatment efficacy. To identify research priorities as well as the resources and infrastructure needed to advance these fields, the National Cancer Institute (NCI) sponsored a workshop titled "Cancer Pharmacogenomics: Setting a Research Agenda to Accelerate Translation" on July 21, 2009, in Bethesda, MD. In this commentary, we summarize and discuss five science-based recommendations and four infrastructure-based recommendations that were identified as a result of discussions held during this workshop. Key recommendations include 1) supporting the routine collection of germline and tumor biospecimens in NCI-sponsored clinical trials and in some observational and population-based studies; 2) incorporating pharmacogenomic markers into clinical trials; 3) addressing the ethical, legal, social, and biospecimen- and data-sharing implications of pharmacogenomic and pharmacoepidemiologic research; and 4) establishing partnerships across NCI, with other federal agencies, and with industry. Together, these recommendations will facilitate the discovery and validation of clinical, sociodemographic, lifestyle, and genomic markers related to cancer treatment response and adverse events, and they will improve both the speed and efficiency by which new pharmacogenomic and pharmacoepidemiologic information is translated into clinical practice.

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Available from: Muin J Khoury,
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    • "Moreover, in relation to oncology, the US National Cancer Institute (NCI) has announced a set of priorities that include treatment response and adverse outcomes associated with chemotherapeutic agents and other medications used to treat cancer (via the Trans-NCI Pharmacogenomics and Pharmacoepidemiology Working Group (PPWG); The recommendation for the corresponding research and development (R&D) agenda is directed towards: (i) supporting the routine collection of germline and tumour biospecimens from clinical trials and population-based studies; (ii) the development of, and support in, the identification of clinical, socio-demographic, lifestyle and genomic markers related to treatment response and/or adverse events; (iii) the incorporation of PGx markers into clinical trials; and (iv) addressing the ethical, legal, social, biospecimen, as well as data-sharing implications of PGx research [4]. "
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