Article

PERAN RADIASI DALAM PENANGANAN ADENOMA HIPOFISE

Seri Kesehatan (Health Series); Vol 8, No 1 (2004): Juni 01/2010;
Source: OAI

ABSTRACT The Role of Irradiation in Hypophyseal Adenoma. Pituitary adenomas are histopathologically benign, however theclinical presentations are often quite severe. These clinical signs are due to the tumor mass effect, hormonaldisturbances or both. Besides that, these tumors often recurred after treatment. The treatment of pituitary tumors havedeveloped greatly with the improvement of techniques of several modalities such as surgery, radiation and medication.Multimodality treatment is often used for optimal results in treating these tumors. Radiotherapy is a cytotoxic agentusing ion radiation for the treatment of pituitary tumors in combination with other methods. Post-surgical radiotherapyhas shown to decrease the recurrence rate significantly (22-71% vs 8-23%). At present there has been rapidimprovements in radiation techniques for pituitary tumors. These developments are not only based upon the increase ofknow-how in computer technology and radiation instruments, but are also based upon the development of cellular andmolecular biology in connection with normal and tumor tissues. The objective in developing radiation methods andtechniques is to create a high radiation dose, homogeneous in the target area with low radiation dose in normal tissue.The development in science and technology, in particular concerning computer science, have created the developmentof radiation techniques and methods. This paper elaborates on several aspects of radiation in the treatment of pituitaryKeywords: pituitary adenoma, radiation, ionizing beam, recurrence

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