Article

Bacteria use type IV pili to walk upright and detach from surfaces.

Department of Bioengineering, California Nano Systems Institute,University of California, Los Angeles, CA 90024, USA.
Science (Impact Factor: 31.48). 10/2010; 330(6001):197. DOI: 10.1126/science.1194238
Source: PubMed

ABSTRACT Bacterial biofilms are structured multicellular communities involved in a broad range of infections. Knowing how free-swimming bacteria adapt their motility mechanisms near surfaces is crucial for understanding the transition between planktonic and biofilm phenotypes. By translating microscopy movies into searchable databases of bacterial behavior, we identified fundamental type IV pili-driven mechanisms for Pseudomonas aeruginosa surface motility involved in distinct foraging strategies. Bacteria stood upright and "walked" with trajectories optimized for two-dimensional surface exploration. Vertical orientation facilitated surface detachment and could influence biofilm morphology.

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Available from: Maxsim L Gibiansky, Jul 02, 2015
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