Correlated firing among major ganglion cell types in primate retina

Systems Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
The Journal of Physiology (Impact Factor: 4.54). 10/2010; 589(Pt 1):75-86. DOI: 10.1113/jphysiol.2010.193888
Source: PubMed

ABSTRACT Retinal ganglion cells exhibit substantial correlated firing: a tendency to fire nearly synchronously at rates different from those expected by chance. These correlations suggest that network interactions significantly shape the visual signal transmitted from the eye to the brain. This study describes the degree and structure of correlated firing among the major ganglion cell types in primate retina. Correlated firing among ON and OFF parasol, ON and OFF midget, and small bistratified cells, which together constitute roughly 75% of the input to higher visual areas, was studied using large-scale multi-electrode recordings. Correlated firing in the presence of constant, spatially uniform illumination exhibited characteristic strength, time course and polarity within and across cell types. Pairs of nearby cells with the same light response polarity were positively correlated; cells with the opposite polarity were negatively correlated. The strength of correlated firing declined systematically with distance for each cell type, in proportion to the degree of receptive field overlap. The pattern of correlated firing across cell types was similar at photopic and scotopic light levels, although additional slow correlations were present at scotopic light levels. Similar results were also observed in two other retinal ganglion cell types. Most of these observations are consistent with the hypothesis that shared noise from photoreceptors is the dominant cause of correlated firing. Surprisingly, small bistratified cells, which receive ON input from S cones, fired synchronously with ON parasol and midget cells, which receive ON input primarily from L and M cones. Collectively, these results provide an overview of correlated firing across cell types in the primate retina, and constraints on the underlying mechanisms.

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Available from: Greg D Field, Jul 28, 2015
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    • "t al . , 2002 , 2004 ) , amphibian ( salamander : Brivanlou et al . , 1998 ) , and various mammalian retinas ( Mastronarde , 1983a , b , c ; DeVries , 1999 ; Hu and Bloomfield , 2003 ; Schnitzer and Meister , 2003 ; Schubert et al . , 2005a , b ; Völgyi et al . , 2005 , 2009 ; Shlens et al . , 2006 ; Hoshi et al . , 2006 ; Trong and Rieke , 2008 ; Greschner et al . , 2011 ) . Ganglion cell spike synchronization has been sug - gested to encode information of the visual scene ( Meister and Berry , 1999 ; Schwartz et al . , 2007 ) to predict stimulus modulation ( Schwartz et al . , 2007 ; Schwartz and Berry , 2008 ) or to serve tem - poral binding of information or salient signaling along the visual axis ( "
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