BCL-2 protein family. Essential regulators of cell death. Preface.

Institute of Biomedical Sciences, FONDAP Center for Molecular Studies of the Cell, University of Chile, Santiago.
Advances in Experimental Medicine and Biology (Impact Factor: 1.96). 01/2010; 687:vii-viii.
Source: PubMed
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    • "Release of proteins, such as cytochrome c, along with increased Bax levels results in cell death through increased levels of key caspases. In contrast, B-cell lymphoma-extra large (Bcl-xL), an antiapoptotic member of the Bcl-2 family, is known to prevent cell death by inhibiting activation of the proapoptotic proteins [35,37-39]. These changes have been well studied in other diseases, as well as other cell types in diabetic retinopathy [34,36]. "
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