Disseminated intravascular coagulation with intracranial haematoma in neonatal congenital syphilis.
ABSTRACT Disseminated intravascular coagulation (DIC) although a well known complication in neonatal sepsis is extremely rare in congenital syphilis and there are scanty reports of this entity in the literature. Intracranial bleeding following DIC in neonatal congenital syphilis is even rarer, and has been reported only once earlier. We are reporting the second case of neonatal DIC with intracranial haematoma due to congenital syphilis in a newborn. Our patient also had clinical and biochemical evidence of hepatitis which predisposes to DIC. Extensive investigations and emergent use of imaging modalities including ultrasound and CT scan led to early diagnosis and treatment in our patient, who could therefore be salvaged from an otherwise life threatening disease.
- SourceAvailable from: Herbert Auer[show abstract] [hide abstract]
ABSTRACT: Objectives: Toxocarosis involving cranial nerves is extremely rare and almost exclusively concerns the optic nerve. Toxocarosis involving the seventh cranial nerve has not been reported. Case report: A 33y male developed left-sided Bell's palsy two days after left-sided otalgia 6y before. Despite extensive diagnostic work-up at that time the cause of Bell's palsy remained unknown. During the following years Bell's palsy slightly improved but retromandibular pain remained almost unchanged and he developed enlarged lymph nodes along the jugular veins, submandibularly, and in the trigonum caroticum. Re-evaluation 6y later revealed an increased titer of serum antibodies against Toxocara canis and a positive Westernblot for Toxocara canis ES-antigen. Despite absent eosinophilia in the serum, toxocarosis was diagnosed and a therapy with albendazole initiated, with benefit for retromandibular pain, but hardly for Bell's palsy or enlarged lymph nodes. CSF investigations after albendazole revealed a positive Westernblot for antibodies against toxocara but absent pleocytosis or eosinophilia, and negative PCR for Toxocara canis. Conclusions: Visceral larva migrans due to Toxocara canis may be associated with Bell's palsy, retromandibular pain, and lymphadenopathy. A causal relation between Bell's palsy and the helminthosis remains speculative. Adequate therapy years after onset of the infestation may be of limited benefit.Revista chilena de infectologia: organo oficial de la Sociedad Chilena de Infectologia 10/2012; 29(5):551-3. · 0.45 Impact Factor
- [show abstract] [hide abstract]
ABSTRACT: Abstract 214 newborns with serious perinatal pathology (posthipoxic syndrome, sepsis, surgical intervention, etc.) were examined in progress, according to 27 parameters including coagulative, trombocitic, antico-agulative and fibrinolitic parts of hemostasis system. It was proved, that neonatal DIC-syndrome (dis-seminated intravascular coagulation) had different hemostasiological patterns, which were connected with the genesis: sepsis, surgical intervention or posthipoxic syndrome. Precise periods of DIC-syndrome are not always presented in newborns. DIC-syndrome with neonatal sepsis has 2 different pat-terns (overcompensated and decompensated). The manifestation of trombo-haemorrhagic disoders and their characteristics depend on the genesis of DIC-syndrome (for instance, an infection process and hy-perbilirubinemia can provide the appearance of haemorrhagic syndrome).The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 10/2013; · 1.36 Impact Factor