Hepcidin and disorders of iron metabolism.

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
Annual review of medicine (Impact Factor: 15.48). 01/2010; 62:347-60. DOI: 10.1146/annurev-med-050109-142444
Source: PubMed

ABSTRACT The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution. Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associated with inflammation, chronic kidney disease and some cancers. Hepcidin deficiency results in iron overload in hereditary hemochromatosis and ineffective erythropoiesis. The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias.