Article

Hepcidin and disorders of iron metabolism

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.
Annual review of medicine (Impact Factor: 15.48). 01/2010; 62:347-60. DOI: 10.1146/annurev-med-050109-142444
Source: PubMed

ABSTRACT The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and its tissue distribution. Pathologically increased hepcidin concentrations cause or contribute to iron-restrictive anemias including anemias associated with inflammation, chronic kidney disease and some cancers. Hepcidin deficiency results in iron overload in hereditary hemochromatosis and ineffective erythropoiesis. The hepcidin-ferroportin axis is the principal regulator of extracellular iron homeostasis in health and disease, and is a promising target for the diagnosis and treatment of iron disorders and anemias.

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    • "Despite their systemic toxicity in different organs, it was recently found to be able to inhibit the expression of hepcidin in hepatocytes through estrogen-like activity, which will lead to increase of serum iron content and reduction of splenic iron content (Wang et al., 2013). PCB-induced iron homeostasis disturbance results in enforced iron supply to other tissues including tumors, which greatly increases the incidence of various cancers and neurological diseases (Ganz and Nemeth, 2011; Zhang et al., 2014). Cadmium (Cd) as an example of heavy metals could disturb systemic iron homeostasis during erythropoiesis. "
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    ABSTRACT: Among the numerous health conditions environmental pollutants can cause, chronic exposure to pollutants including persistent organic pollutants (POPs) and heavy metals has been shown to disturb a specific biological homeostatic process, the iron metabolism in human body. Disorders of iron metabolism are among the common diseases of humans and encompass a broad spectrum of diseases with different clinical manifestations, ranging from anemia to iron overload, and possibly to neurodegenerative diseases and cancer. Hepcidin-ferroportin (FPN) signaling is one of the key mechanisms responsible for iron supply, utilization, recycling, and storage, and recent studies demonstrated that exposure to environmental pollutants including POPs and heavy metals could lead to disruption of the hepcidin-FPN axis along with disordered systemic iron homeostasis and diseases. This article introduces and highlights the accompanying review article by Drs. Xu and Liu in this journal, which elaborates in detail the adverse effects of environmental pollutants on iron metabolism, and the mechanisms responsible for these toxicological outcomes. It also points out the knowledge gaps still existing in this subject matter. Research that will fill these gaps will improve our understanding of the issue and provide useful information to prevent or treat diseases induced by environmental pollutants. Copyright © 2015. Published by Elsevier B.V.
    Journal of Environmental Sciences 06/2015; DOI:10.1016/j.jes.2015.06.001 · 1.92 Impact Factor
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    • "Increased hepcidin expression causes iron deficiency anemia; in contrast, decreased hepcidin expression leads to body iron overload (Ganz and Nemeth, 2011). Iron overload is recognized as a risk factor for cancers, neurodegenerative diseases and arthropathy (Ganz and Nemeth, 2011; Lehmann et al., 2006; Weinberg, 2006). Meanwhile, iron overload is also considered as a risk for osteopenia and osteoporosis (Haidar et al., 2011; Valenti et al., 2009; Weinberg, 2008). "
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    • "Increased hepcidin expression causes iron deficiency anemia; in contrast, decreased hepcidin expression leads to body iron overload (Ganz and Nemeth, 2011). Iron overload is recognized as a risk factor for cancers, neurodegenerative diseases and arthropathy (Ganz and Nemeth, 2011; Lehmann et al., 2006; Weinberg, 2006). Meanwhile, iron overload is also considered as a risk for osteopenia and osteoporosis (Haidar et al., 2011; Valenti et al., 2009; Weinberg, 2008). "
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