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    ABSTRACT: Resumo Na maioria dos mamíferos a atividade da enzima lactase diminui na parede intestinal após o desmame, caracterizando a hipolactasia primária que provoca sintomas de intolerância à lactose. A intensidade dos sintomas de distensão, flatulência, dor abdominal e diarreia variam, dependendo da quantidade de lactose ingerida, e aumentam com o passar da idade. A hipolactasia é determinada geneticamente, porém uma mutação ocorreu para que fizesse parte da humanidade tolerar o leite na idade adulta. O diagnóstico é feito por teste de tolerância, empregando a lactose como desafio. Com a descoberta dos finlandeses do polimorfismo associado com a persistência da lactase, principalmente no norte da Europa, o exame genético passou a ser outra ferramenta diagnóstica mais confortável para o intolerante. No Brasil, 43% dos brancos e dos mulatos têm alelo de persistência da lactase, sendo a hipolactasia mais frequente entre os negros e japoneses. Entretanto, na prática clínica indivíduos com hipolactasia podem ser orientados a consumir alguns derivados do leite e alimentos contendo lactose sem apre-sentar sintomas de intolerância, enquanto que outros terão que fazer restrição de lactose na dieta. UniterMos: Intolerância à lactose. Fatores de lactose. Epidemiologia. Biologia molecular.
    Revista da Associação Médica Brasileira 01/2010; 56(2). · 0.92 Impact Factor
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    ABSTRACT: Women's diets are of interest as they not only impact on wellbeing and risk of chronic disease in women themselves, but also influence pregnancy outcomes and infant health. UK dietary surveys show that, while some improvements have occurred, intakes of key micronutrients, particularly iron, vitamin D, calcium and folate remain below recommended levels. Women's diets are also too high in saturated fat and salt, and low in fibre, oily fish and fruits and vegetables. Evidence suggests that certain chronic conditions are influenced by dietary components, e.g. inadequate calcium and vitamin D intakes reduce bone density, salt and saturated fat increase cardiovascular disease risk, excessive alcohol intakes increase cancer risk, low intakes of long chain n-3 fatty acids may adversely affect fetal development and mental health, while adequate folic acid reduces the risk of birth defects. Focused health initiatives are needed to improve diet quality in women, particularly school-aged girls, women planning a pregnancy, those living in areas of deprivation and elderly women. Vitamin and mineral supplements, and fortified foods may have a role to play alongside dietary improvements in helping women to achieve optimal diet quality.
    Nutrition Bulletin 05/2010; 35(2):126 - 137.
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    ABSTRACT: Polydextrose (PDX) is a highly branched, randomly bonded glucose polymer which is not digested in the upper gastrointestinal tract, but is slowly fermented throughout the colon. It has been widely acknowledged as a soluble fibre, and human clinical, animal and in vitro studies have all demonstrated physiological effects associated with this feature. These effects include improving gut health, reducing glycaemic impact and inducing satiety (1–3). The high tolerance and technological properties of PDX allow the development of food products with a variety of nutritional improvements without compromising taste and texture profile.
    Nutrafoods. 04/2011; 10(2-3).

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