An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging
ABSTRACT There are many different visible signs of skin aging. These include wrinkles, hyperpigmentation, lack of firmness, poor texture, enlarged pores, and dryness. While there are many topical agents that claim to deliver wide-spectrum anti-aging benefits, few target all of the signs of skin aging to the same extent. Salicin, an extract from white willow bark, has been researched as a potent anti-inflammatory agent when taken orally. Based on unpublished in-house comprehensive consumer clinical studies, it is believed salicin may have anti-aging capabilities when applied topically to human skin.
This research evaluated the effect of a topical serum formulation containing salicin at 0.5% on the visible signs of skin aging.
This single-center study enrolled 30 female subjects, showing mild to moderate signs of aging, between the ages of 35 and 70 having Fitzpatrick skin types ranging between I and IV. Subjects used the study serum product containing 0.5% salicin on their face twice daily for 12 weeks. Ordinal grading on a nine-point scale (0 = none, 1-3 = mild, 4-6 = moderate, 7-9 = severe) of facial fine lines, molted pigmentation, uneven skin tone, tactile roughness, global firmness appearance, jaw-line contour, radiance, and overall appearance was performed by investigator at baseline, week 1, week 4, week 8, and week 12. Digital photography, ultrasound, cutometry, and corneometry measurements were also performed at each time point.
Twenty-nine of 30 subjects successfully completed the study. No tolerability issues were reported. The clinical investigator found statistically significant improvements in wrinkles, tactile roughness, pore size, radiance, and overall appearance at week 1 time point (P ≤ 0.05) against baseline and statistically significant improvements in mottled pigmentation, global firmness, and jaw-line contour at week 4 time point (P ≤ 0.05) against baseline. Cutometry, corneometry, and ultrasound measurements showed significant improvements at week 12 time point (P ≤ 0.05) against baseline.
Based on the findings from this study, it can be concluded that salicin has the ability to reduce the visible signs of skin aging when applied topically.
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ABSTRACT: Facial appearance is regarded as a typical index of ageing. However, people of the same age do not necessarily show the same degree of the facial appearance. The ageing of facial skin proceeds relatively slowly and therefore requires long-term follow-up to elucidate the mechanism of ageing changes. The purpose of this study was to identify facial skin parameters contributing the subjective impression of the overall ageing and characterize the degree of skin ageing by a 11 year longitudinal skin monitoring. One-hundred-eight healthy Japanese females excluded outside workers aged 5-64 at 1999, and lived in Akita, Japan till 2010 were enrolled. Facial images were collected to quantify various skin optical parameters. Skin colour, hydration and barrier function were measured with Chromameter, Corneometer and TEWAmeter, respectively. The visual evaluation of the overall facial skin ageing impression was also carried out. The skin parameters contributing visible impression of skin ageing were identified by variable importance in projection analysis, and the degree of facial skin ageing over 11 years was statistically classified by a cluster analysis. Facial skin parameters that comprehensively influenced visible skin ageing, including hyperpigmented spots, wrinkles and texture were studied. The Skin Ageing Score calculated from these three skin factors was used to classify the subjects into a mild, age-appropriate, and severe skin ageing group. The mild skin ageing group maintained significant better both skin optical and physical conditions. Variability and classification of the degree of facial skin ageing appearance were studied from this longitudinal research.Journal of dermatological science 12/2011; 64(3):229-36. DOI:10.1016/j.jdermsci.2011.09.009 · 3.34 Impact Factor
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