Article
Regulatory T-cell number is increased in chronic lymphocytic leukemia patients and correlates with progressive disease.
IRCCS Casa Sollievo della Sofferenza Hospital, 71013 San Giovanni Rotondo, Italy.
Leukemia research (impact factor:
2.36).
09/2010;
35(3):363-8.
DOI:10.1016/j.leukres.2010.08.010
pp.363-8
Source: PubMed
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Citations (0)
- Cited In (3)
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Article: Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic options.
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ABSTRACT: Chronic lymphocytic leukemia (CLL) cells display features consistent with a defect in apoptosis and exhibit prolonged survival in vivo. Survival of these malignant cells is influenced by interactions with non-leukemic cells located in permissive niches in lymphoid organs. Leukemic cells subvert the normal architecture of the lymphoid organs, recruiting stromal cells, dendritic cells and T lymphocytes, all reported as playing active roles in the survival and proliferation of CLL. The same survival-promoting environment also rescues/protects leukemic cells from cytotoxic therapies, giving way to disease relapse. This review summarizes and discusses current knowledge about the intricate network of soluble and cell-bound signals regulating the life and death of CLL cells in different districts. At the same time, it seeks to hone in on which discrete molecular elements are best suited as targets for treating this still incurable disease.Cancer letters 08/2012; · 4.86 Impact Factor -
Article: Increased Frequency of CD8(+) and CD4(+) Regulatory T Cells in Chronic Lymphocytic Leukemia: Association With Disease Progression.
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ABSTRACT: Little is known regarding the immunobiology of regulatory T (Treg) cells in hematopoietic malignancies, particularly in chronic lymphocytic leukemia (CLL). In the present study, we showed that the frequencies of CD8(+) and CD4(+) Treg cells were significantly increased in progressive as compared with indolent CLL patients and normal subjects. Enriched CD4(+) Treg cells induced a similar level of inhibition in polyclonally activated B cells and effector T cells from CLL patients and normal subjects. Our results suggest that the increase in circulating Treg cells may result in downregulation of tumor-specific immune response, leading to tumor expansion and disease progression.Cancer Investigation 01/2013; · 1.85 Impact Factor -
Dataset: Increased Frequency of CD8
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Keywords
40 normal healthy volunteers
absolute CD38+ B-cell number
clinical stage
correlate
cytogenetic abnormalities
IgVH mutational status
LDH levels
Regulatory T-cells
significant role
Treg cells
untreated chronic lymphocytic leukemia
ZAP-70 expression
