Personalization of cubic Hermite meshes for efficient biomechanical simulations.

Computing Laboratory, University of Oxford, UK.
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention 01/2010; 13(Pt 2):380-7. DOI: 10.1007/978-3-642-15745-5_47
Source: PubMed

ABSTRACT Cubic Hermite meshes provide an efficient representation of anatomy, and are useful for simulating soft tissue mechanics. However, their personalization can be a complex, time consuming and labour-intensive process. This paper presents a method based on image registration and using an existing template for deriving a patient-specific cubic Hermite mesh. Its key contribution is a solution to customise a Hermite continuous description of a shape with the use of a discrete warping field. Fitting accuracy is first tested and quantified against an analytical ground truth solution. To then demonstrate its clinical utility, a generic cubic Hermite heart ventricular model is personalized to the anatomy of a patient, and its mechanical stability is successfully tested. The method achieves an easy, fast and accurate personalization of cubic Hermite meshes, constituting a crucial step for the clinical adoption of physiological simulations.

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    ABSTRACT: This series of notes was prepared for the COMMAS summer school in 2013. The primary object of these notes is to provide additional material and references to augment the seminar slides introduced in class. Over the three part lecture series, the slides as well as these notes aim to expose students to the issues facing the cardiac clinical community and show the potential for modeling to address these issues. These notes focus on: ◦ Understanding Cardiac Multi-Scale / Multi-Physics Issues ◦ Understanding the Anisotropic Hyperelastic Behavior of Cardiac Tissue ◦ Understanding Cauchy’s first Law, Solution with Finite Element Method ◦ Understanding the Basic issues of Incompressibility This material is by no means comprehensive, but instead seeks to provide an introduction to the field of cardiac biomechanics, and stress its relevance as both an important clinical research area as well as a challenging system of study. Dr. David Nordsletten Dept of Biomedical Engineering, KCL

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