Article

Coexistence of two chronic neuropathies in a young child: Charcot-Marie-Tooth disease type 1A and chronic inflammatory demyelinating polyneuropathy.

Department of Neurosciences and Behavior Sciences, School of Medicine of Ribeirão Preto, University of São Paulo, SP 14049-900, Brazil.
Muscle & Nerve (impact factor: 2.37). 10/2010; 42(4):598-600. DOI:10.1002/mus.21753
Source: PubMed

ABSTRACT We report an 18-month-old Charcot-Marie-Tooth type 1A (CMT1A) patient who developed a rapid-onset neuropathy, with proximal and distal weakness, and non-uniform nerve conduction studies. The neuropathy responded well to immunomodulation, confirming the coexistence of an inherited and an inflammatory neuropathy. Unexpected clinical and/or electrophysiological manifestations in CMT1A patients should alert clinicians to concomitant inflammatory neuropathy. In addition, this association raises reflections about disease mechanism in CMT1A.

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Keywords

18-month-old Charcot-Marie-Tooth type 1A
 
CMT1A
 
CMT1A patients
 
concomitant inflammatory neuropathy
 
disease mechanism
 
immunomodulation
 
inflammatory neuropathy
 
neuropathy
 
non-uniform nerve conduction studies
 
proximal
 
rapid-onset neuropathy
 
Unexpected clinical