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GWAS identifies a common breast cancer risk allele among BRCA1 carriers

Peter Kraft is at the Harvard School of Public Health, Boston, Massachusetts, USA.
Nature Genetics (Impact Factor: 29.65). 10/2010; 42(10):819-20. DOI: 10.1038/ng1010-819
Source: PubMed

ABSTRACT A genome-wide association study conducted among women with deleterious BRCA1 mutations has identified a common allele associated with breast cancer risk in BRCA1 carriers and estrogen receptor-negative breast cancer in the general population. This suggests that genetic association studies focused on particular subtypes may provide further insight into complex diseases.

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