Article

Serum KL-6 levels in lung cancer patients with or without interstitial lung disease.

Division of Respiratory Medicine, Tsukuba Medical Center, Ibaraki, Japan.
Journal of Clinical Laboratory Analysis (impact factor: 1.38). 01/2010; 24(5):295-9. DOI:10.1002/jcla.20404 pp.295-9
Source: PubMed

ABSTRACT It is not known whether lung cancer patients with interstitial lung disease (ILD) might have higher serum levels of KL-6, a high molecular weight glycoprotein classified as a polymorphic epithelial mucin. In addition, prognosis of these patients with elevated serum KL-6 levels might be poorer than that with normal KL-6 levels, but it has not been well clarified.
Serum KL-6 levels in 273 lung cancer patients with or without ILD, and prognostic significance of elevated serum KL-6 levels in these patients were studied using uni- and multivariate analyses.
Serum KL-6 levels were elevated (>500 U/ml) in 73.5% of lung cancer patients with ILD and in 33.7% of those without ILD. Serum KL-6 levels in lung cancer patients with ILD were significantly higher than those without ILD. In lung cancer patients with ILD, elevated serum KL-6 has no prognostic significance, but in those without ILD, however, it was one of the unfavorable prognostic factors.
Elevated serum KL-6 levels can be observed in lung cancer patients both with and without ILD. Having ILD has strong prognostic impact in patients with lung cancer. In those without ILD, however, elevated KL-6 levels may be related to poor prognosis.

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Keywords

273 lung cancer patients
 
Elevated serum KL-6 levels
 
ILD
 
interstitial lung disease
 
KL-6
 
KL-6 levels
 
lung cancer
 
lung cancer patients
 
molecular weight glycoprotein
 
multivariate analyses
 
normal KL-6 levels
 
polymorphic epithelial mucin
 
poor prognosis
 
prognosis
 
serum KL-6
 
serum KL-6 levels
 
unfavorable prognostic factors
 
uni-
 

Kunihiko Miyazaki