Near-infrared fluorescent nanoprobes for cancer molecular imaging: Status and challenges

Molecular Imaging Program at Stanford (MIPS), Department of Radiology, Bio-X Program and Stanford Cancer Center, Stanford University School of Medicine, Stanford, CA 94305, USA.
Trends in Molecular Medicine (Impact Factor: 9.45). 12/2010; 16(12):574-83. DOI: 10.1016/j.molmed.2010.08.006
Source: PubMed


Near-infrared fluorescence (NIRF) imaging promises to improve cancer imaging and management; advances in nanomaterials allow scientists to combine new nanoparticles with NIRF imaging techniques, thereby fulfilling this promise. Here, we present a synopsis of current developments in NIRF nanoprobes, their use in imaging small living subjects, their pharmacokinetics and toxicity, and finally their integration into multimodal imaging strategies. We also discuss challenges impeding the clinical translation of NIRF nanoprobes for molecular imaging of cancer. Whereas utilization of most NIRF nanoprobes remains at a proof-of-principle stage, optimizing the impact of nanomedicine in cancer patient diagnosis and management will probably be realized through persistent interdisciplinary amalgamation of diverse research fields.

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Available from: Zhen Cheng, Jan 06, 2014
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    Journal of Colloid and Interface Science 06/2015; 457:27-34. DOI:10.1016/j.jcis.2015.06.046 · 3.37 Impact Factor
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    • "The reaction occurs at room temperature, showing a high degree of solvent and pH insensitivity, and high chemoselectivity (the azide and alkyne are inert to react with numerous functional groups under the typically mild reaction conditions). In fact, the reaction succeeds over a broad temperature range, is insensitive to aqueous conditions and occurs in a pH range between 4 and 12 (Hein and Fokin, 2010; Le et al., 2010). The copper catalyzed azide-alkyne cycloaddition occurs between an organic azide and a terminal acetylene. "
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    Frontiers in Chemistry 06/2014; DOI:10.3389/fchem.2014.00048
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    • "On the other hand, fluorescence spectroscopy is a high sensitive technique, with very low detection limits, but in vivo, this emission could be highly reduced [13]. Thus, the research on the design of dyes that emit in the far-red (above 600e700 nm) has increased, because they have a low background, and far red light can penetrate deeper in living cells, facilitating the in vivo studies [14]. In this work are presented four compounds, 1e4, derivatives from vitamin B6 bearing signalling units that emit from the UVevisible light to the far red light. "
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