Article

Influenza exits the cell without an ESCRT.

Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Cell (Impact Factor: 31.96). 09/2010; 142(6):839-41. DOI: 10.1016/j.cell.2010.08.036
Source: PubMed

ABSTRACT Many enveloped viruses depend on the membrane remodeling machinery of their host cells to complete their life cycle. In this issue, Rossman et al. (2010) now demonstrate that influenza virus possesses its own device for releasing nascent virus particles from the plasma membrane, the M2 proton-selective ion channel, which can substitute for the host cell's ESCRT pathway.

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