Article

Cellular sources and immune functions of interleukin-9.

Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.
Nature Reviews Immunology (Impact Factor: 32.25). 10/2010; 10(10):683-7. DOI: 10.1038/nri2848
Source: PubMed

ABSTRACT Interleukin-9 (IL-9) has attracted renewed interest owing to the identification of its expression by multiple T helper (T(H)) cell subsets, including T(H)2 cells, T(H)9 cells, T(H)17 cells and regulatory T (T(Reg)) cells. Here, we provide a broad overview of the conditions that are required for cells to produce IL-9 and describe the cellular targets and nature of the immune responses that are induced by IL-9.

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