Reduction of immune activation with chloroquine therapy during chronic HIV infection

Human Immunology Section, NIH Vaccine Research Center, Bethesda, MD 20892-3005, USA.
Journal of Virology (Impact Factor: 4.65). 11/2010; 84(22):12082-6. DOI: 10.1128/JVI.01466-10
Source: PubMed

ABSTRACT Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38(+) HLA-DR(+) CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals.

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Available from: William M Stauffer, Aug 10, 2015
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    • "So far, studies employing these and other anti-inflammatory molecules have rendered contrasting results (Hatano, 2013). Thus, chloroquine administration has been shown to decrease levels of T cell activation (Murray et al., 2010) but produce faster CD4þ T cell loss when used for longer periods of time (Paton et al., 2012). A better knowledge of the best timing to implement interventions aimed at decreasing persistent immune activation is warranted. "
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    • "Clinical trials have supported the use of chloroquine to reduce immune activation in HIV-infected patients. When chloroquine was administered to ART-naïve subjects for 2 months, patients showed immunological improvement, as the frequency of CD38+ HLA-DR + CD8+ T cells, proliferation of T cells, and circulating LPS levels were signi fi cantly reduced (Murray et al. 2010 ) . Six months of chloroquine administration to HIV-infected clinical nonresponders, who had inadequate reconstitution of CD4+ T cells despite suppressive ART, had decreased frequency of activated T cells, decreased circulating LPS, decreased production of in fl ammatory cytokines (IL-6, TNF-alpha) in response to ex vivo stimulation of TLR ligands, and evidenced improved CD4+ T cell counts and pDC numbers (Piconi et al. 2011 ) . "
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