Visuospatial perception and navigation in Parkinson’s disease

College of Health and Rehabilitation Sciences, Sargent College, Department of Psychology, Boston University, Boston, MA 02215, United States.
Vision research (Impact Factor: 1.82). 11/2010; 50(23):2495-504. DOI: 10.1016/j.visres.2010.08.029
Source: PubMed


A shifted field of view, an altered perception of optic flow speed, and gait asymmetries may influence heading direction in Parkinson's disease (PD). PD participants (left body-side onset, LPD, n=14; right body-side onset, RPD, n=9) and Healthy Control participants (n=17) walked a virtual hallway in which the optic flow speeds of the walls varied. Three-dimensional kinematics showed participants veered away from the faster moving wall. Although veering normally occurs toward the side with smaller step length, in both LPD and RPD this bias was overridden by a shifted field of view, which caused veering in the opposite direction, toward the side of the brain with more basal ganglia damage.

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    • "Several of the visuospatial deficits found in PD are similar to (though milder than) those suffering from hemispatial neglect, a disorder characterized by severe visuospatial deficits, including not attending or not responding to stimuli presented to the side of the body contralateral to the predominant brain lesion, as well as nonspatial deficits such as difficulty sustaining attention (Corbetta & Shulman, 2011). For example, several PD studies show lateralized spatial biases analogous to neglect on tasks of line bisection (Laudate, Neargarder, & Cronin-Golomb, 2013; Lee et al., 2001), navigation (Davidsdottir et al., 2008; Young et al., 2010), and visual exploration (Ebersbach et al., 1996). On tasks of line bisection, Lee et al. (2001) found that LPD, but not RPD, showed midpoint deviations that were similar to individuals with CONTACT: Joseph DeGutis "
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    ABSTRACT: Individuals with Parkinson's disease (PD) commonly demonstrate lateralized spatial biases, which affect daily functioning. Those with PD with initial motor symptoms on the left body side (LPD) have reduced leftward attention, whereas PD with initial motor symptoms on the right side (RPD) may display reduced rightward attention. We investigated whether a sustained attention training program could help reduce these spatial biases. Four non-demented individuals with PD (2 LPD, 2 RPD) performed a visual search task before and after 1 month of computer training. Before training, all participants showed a significant spatial bias and after training, all participants' spatial bias was eliminated.
    Neurocase 09/2015; DOI:10.1080/13554794.2015.1088035 · 1.12 Impact Factor
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    • "Hallucinations affect from 8% to 40% of PD adults throughout the course of the disease and are a risk factor for dementia and nursing home placement (Barnes & David, 2001; Fenelon, Mahieux, Huon, & Ziegler, 2000; Goetz, Leurgans, Pappert, Raman, & Stemer, 2001). A potential factor contributing to the resolution of perceptual ambiguity is visual dependence, which is defined as the tendency to rely on externally provided (visual) information to guide behavior, as occurs in PD (Azulay, Mesure, Amblard, & Pouget, 2002; Davidsdottir, Wagenaar, Young, & Cronin-Golomb, 2008; Young et al., 2010). Several studies have found that enhancing low-level physical properties of a stimulus, such as contrast, may normalize the cognitive performance of individuals with PD relative to healthy younger and older adults (Amick, Cronin-Golomb, & Gilmore, 2003; Cools, Rogers, Barker, & Robbins, 2009; Laudate et al., 2012; Toner et al., 2012). "
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    ABSTRACT: Parkinson's disease (PD) and normal aging have been associated with changes in visual perception, including reliance on external cues to guide behavior. This raises the question of the extent to which these groups use visual cues when disambiguating information. Twenty-seven individuals with PD, 23 normal control adults (NC), and 20 younger adults (YA) were presented a Necker cube in which one face was highlighted by thickening the lines defining the face. The hypothesis was that the visual cues would help PD and NC to exert better control over bistable perception. There were three conditions, including passive viewing and two volitional-control conditions (hold one percept in front; and switch: speed up the alternation between the two). In the Hold condition, the cue was either consistent or inconsistent with task instructions. Mean dominance durations (time spent on each percept) under passive viewing were comparable in PD and NC, and shorter in YA. PD and YA increased dominance durations in the Hold cue-consistent condition relative to NC, meaning that appropriate cues helped PD but not NC hold one perceptual interpretation. By contrast, in the Switch condition, NC and YA decreased dominance durations relative to PD, meaning that the use of cues helped NC but not PD in expediting the switch between percepts. Provision of low-level cues has effects on volitional control in PD that are different from in normal aging, and only under task-specific conditions does the use of such cues facilitate the resolution of perceptual ambiguity. (JINS, 2015, 21, 1-10).
    Journal of the International Neuropsychological Society 03/2015; 21(02):1-10. DOI:10.1017/S1355617715000065 · 2.96 Impact Factor
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    • "We examined the functional neural correlates of optic flow processing in PD in light of existing behavioral evidence suggesting that disruption in optic flow processing may underlie visuospatial deficits observed behaviorally (Davidsdottir et al., 2008; Young et al., 2010). In healthy young adults, visual cortical areas V6, V3A, and MT+ have been characterized as extracting coherent motion cues selective for self-motion (Cardin and Smith, 2010, 2011; Pitzalis et al., 2010). "
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    ABSTRACT: The visual input created by the relative motion between an individual and the environment, also called optic flow, influences the sense of self-motion, postural orientation, veering of gait, and visuospatial cognition. An optic flow network comprising visual motion areas V6, V3A, and MT+, as well as visuo-vestibular areas including posterior insula vestibular cortex (PIVC) and cingulate sulcus visual area (CSv), has been described as uniquely selective for parsing egomotion depth cues in humans. Individuals with Parkinson's disease (PD) have known behavioral deficits in optic flow perception and visuospatial cognition compared to age- and education-matched control adults (MC). The present study used functional magnetic resonance imaging (fMRI) to investigate neural correlates related to impaired optic flow perception in PD. We conducted fMRI on 40 non-demented participants (23 PD and 17 MC) during passive viewing of simulated optic flow motion and random motion. We hypothesized that compared to the MC group, PD participants would show abnormal neural activity in regions comprising this optic flow network. MC participants showed robust activation across all regions in the optic flow network, consistent with studies in young adults, suggesting intact optic flow perception at the neural level in healthy aging. PD participants showed diminished activity compared to MC particularly within visual motion area MT+ and the visuo-vestibular region CSv. Further, activation in visuo-vestibular region CSv was associated with disease severity. These findings suggest that behavioral reports of impaired optic flow perception and visuospatial performance may be a result of impaired neural processing within visual motion and visuo-vestibular regions in PD.
    Frontiers in Integrative Neuroscience 07/2014; 8:57. DOI:10.3389/fnint.2014.00057
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