Article

Rhodium-catalysed conjugate addition of arylboronic acids to enantiopure dehydroamino acid derivatives.

Department of Chemistry, University of Bath, Claverton Down, Bath, UKBA2 7AY.
Organic & Biomolecular Chemistry (impact factor: 3.7). 11/2010; 8(22):5120-5. DOI:10.1039/c0ob00158a pp.5120-5
Source: PubMed

ABSTRACT The rhodium-catalysed conjugate addition of arylboronic acids to an enantiopure acceptor derived from (R)-S-methylcysteine proceeds under substrate control to provide a range of functionalised phenylalanine derivatives with excellent stereocontrol via a highly diastereoselective protonation.

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Keywords

enantiopure acceptor
 
excellent stereocontrol
 
rhodium-catalysed conjugate addition
 
substrate control