Metalloantibiotics and antibiotic mimics - an overview
ABSTRACT The metal cores of metalloantibiotics offer a unique prospect to probe their structure and function at functional groups that can readily be distinguished from the surrounding environment. Metalloantibiotics interact with DNA, RNA, proteins, receptors and lipids, making them very unique and specific. Metal contamination potentially contributes to the maintenance and spread of antibiotic resistance factors. Certain metal ions binding with antibiotics (bleomycin, histatin, and bacitracin) and the Alzheimer’s disease-related β-amyloid peptide exhibited specific biological activities and chemical reactivities. Bismuth-fluoroquinolone complexes have the potential to be developed as drugs against H. pylori related ailments. Antibiotics metal complexes as well as mixed antibiotics metal complexes were found more effective as chemotherapy agents than their parent antibiotics. The addition of vitamin C markedly enhanced the activities of both pomegranates/Fe (II) and pomegranates /Cu (II) combinations against S. aureus.
Full-textDOI: · Available from: Bhupinder Sekhon, Oct 29, 2014
- SourceAvailable from: Anupam Roy
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- "Transition metals are generally preferred in metalloantibiotics and are present in very low concentration in vivo. The ligand environment of transition metal ions can generally change considerably upon administration of a therapeutically effective dose of an antibacterial drug (Sekhon, 2010). Some strategies are followed to synthesize metal nanoparticles using antibiotics as in situ reducing and capping agent. "
ABSTRACT: Bacterial infections are raising serious concern across the globe. The effectiveness of conventional antibiotics is decreasing due to global emergence of multi-drug-resistant (MDR) bacterial pathogens. This process seems to be primarily caused by an indiscriminate and inappropriate use of antibiotics in non-infected patients and in the food industry. New classes of antibiotics with different actions against MDR pathogens need to be developed urgently. In this context, this review focuses on several ways and future directions to search for the next generation of safe and effective antibiotics compounds including antimicrobial peptides, phage therapy, phytochemicals, metalloantibiotics, lipopolysaccharide, and efflux pump inhibitors to control the infections caused by MDR pathogens.Frontiers in Pharmacology 05/2014; 5:105. DOI:10.3389/fphar.2014.00105 · 3.80 Impact Factor
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- "Pharmacokinetics and bioavailability of TC are affected by its coordination with metal ions such as calcium in blood plasma and magnesium ion in the intracellular medium . By combining with the copper, zinc, iron, and other trace metal elements in enzymes such as collagenase, tetracyclines inhibit the enzymatic destruction of tissues . "
ABSTRACT: UV-visible and atomic spectrophotometry and HPLC techniques were applied for the determination of tetracycline (TC) in pharmaceutical preparations via complexation of the drug with Au(III) and Hg(II) ions in solutions. The mole ratio of TC to metal ions was 1 : 1. Maximum peak absorption at λ 425 and 320 nm for the two ions, respectively, was optimized at heating temperature 75°C for 15 minutes at pH = 4 followed by the extraction with ethyl acetate. The percentage of extraction and stability constants for the two complexes was 95.247, 95.335% and 2.518 × 10(4), 1.162 × 10(5) M(-1), respectively. HPLC method was applied without extraction process. The analytical data obtained from direct calibration curves of UV-visible absorption, FAAS, and HPLC for Au(III) complexes were recovery (100.78, 104.85, and 101.777%, resp.); detection limits (0.7403, 0.0997, and 2.647 μ g/ml, resp.); linearity (5-70, 5-30, and 10-150 μ g/ml, resp.), and correlation coefficient (0.9991, 0.9967, and 0.9986, resp.). The analytical data obtained from direct calibration curves for Hg(II) complexes by UV-visible spectrophotometry and HPLC were recovery (100.95 and 102.000%, resp.); detection limits (0.5867 and 2.532 μ g/ml, resp.); linearity (5-70 and 10-150 μ g/ml, resp.); and correlation coefficients (0.9989 and 0.9997, resp.).International Journal of Analytical Chemistry 06/2013; 2013(4):305124. DOI:10.1155/2013/305124 · 1.00 Impact Factor