Article

When chiral product and catalyst are the same: discovery of asymmetric organoautocatalysis

Department of Chemistry and Pharmacy, Chair of Organic Chemistry I, University of Erlangen-Nuremberg, Henkestrasse 42, 91054 Erlangen, Germany.
Chemical Communications (Impact Factor: 6.72). 11/2010; 46(41):7662-9. DOI: 10.1039/c0cc02305a
Source: PubMed

ABSTRACT The process of asymmetric organoautocatalysis appears to be a natural extension to asymmetric organocatalysis, and holds implications for models on the origin of biological homochirality. The discovery of asymmetric organoautocatalysis (i.e. the process in which the chiral product of a purely organic reaction acts as an organocatalyst for its own formation under conservation of its absolute configuration) and more recent reports on related systems are discussed in this review.

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Jun 6, 2014