A novel controlled release drug delivery system for multiple drugs based on electrospun nanofibers containing nanoparticles.

Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China.
Journal of Pharmaceutical Sciences (Impact Factor: 3.13). 12/2010; 99(12):4805-11. DOI: 10.1002/jps.22189
Source: PubMed

ABSTRACT This study describes development of a novel controlled drug release system for multiple drugs, it consisted of Chitosan nanoparticles/PCL composite electrospun nanofibers with core-sheath structures. Two model agents' rhodamine B and naproxen were successfully loaded in the core and sheath region respectively. The behavior of these two agents demonstrated a good controlled release and temporality, providing a new way to obtain program or temporality release for multiple agents. Particularly, this is potential applications in the field of tissue engineering, sutures and wound dressings.

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