A novel controlled release drug delivery system for multiple drugs based on electrospun nanofibers containing nanoparticles.

Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China.
Journal of Pharmaceutical Sciences (Impact Factor: 3.01). 12/2010; 99(12):4805-11. DOI: 10.1002/jps.22189
Source: PubMed

ABSTRACT This study describes development of a novel controlled drug release system for multiple drugs, it consisted of Chitosan nanoparticles/PCL composite electrospun nanofibers with core-sheath structures. Two model agents' rhodamine B and naproxen were successfully loaded in the core and sheath region respectively. The behavior of these two agents demonstrated a good controlled release and temporality, providing a new way to obtain program or temporality release for multiple agents. Particularly, this is potential applications in the field of tissue engineering, sutures and wound dressings.

  • [Show abstract] [Hide abstract]
    ABSTRACT: This review explores the potential of electrospun nanofibers for drug delivery applications. In the first section, some of the key challenges in drug delivery as well as the promise of electrospun drug loaded nanofibers are highlighted. Techniques of drug incorporation into nanofibers such as blending, surface modification and co-axial electrospinning are detailed. The major requirements of drug eluting scaffolds such as biocompatibility and biodegradability, efficient drug control and release, and adequate mechanical performance are addressed. Drug release kinetics, biodegradability and mechanical properties can be controlled by careful selection of polymers and electrospinning processing parameters while biocompatibility of electrospun mats may be enhanced through surface modification of the nanofibers. The major applications as well as the routes of administration of the drug-loaded electrospun nanostructures are discussed. Currently available drug eluting nanofibrous mats for applications ranging from cancer therapy to wound dressings as well as their preclinical trials are also reviewed.
    Journal of Biomedical Nanotechnology 09/2015; 10(9). DOI:10.1166/jbn.2014.1885 · 7.58 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Composite nanofibers have received a lot of attention due to their multifunctional behavior. Some interesting properties can be induced in nanofiber through incorporation of nanoparticles. In present work, PVA-pectin-magnetite nanofiber was prepared using electrospinning method. The morphological studies of the composite nanofibers were performed by AFM (atomic force microscope) and by FE-SEM (field emission scanning electron microscope). The chemical composition of the imaged nanofibers was determined from energy dispersive X-ray spectrometry (EDX). The magnetic property of the nanofibers was due to incorporation of Fe 3 O 4 nanoparticles, which was corroborated from VSM study exhibiting ferromagnetic property and negligible coercivity (saturation magnetization = 9. 34 emu/g). The Fe 3 O 4 phase was further confirmed form XRD study. The loading and release of diclofenac sodium drug from the as-synthesized nanofibers was studied by UV-Visible spectroscopy. The loading of drug was 56. 78 µg mg -1 and exhibited burst release at pH 7. 4 PBS. 630 Pritam Roy and Raj Kumar Dutta
  • [Show abstract] [Hide abstract]
    ABSTRACT: A series of polyvinylpyrrolidone fibers loaded with paracetamol (PCM) and caffeine (CAF) was fabricated by electrospinning and explored as potential oral fast-dissolving films. The fibers take the form of uniform cylinders with smooth surfaces, and contain the drugs in the amorphous form. Drug–polymer intermolecular interactions were evidenced by infrared spectroscopy and molecular modeling. The properties of the fiber mats were found to be highly appropriate for the preparation of oral fast dissolving films: their thickness is around 120–130 μm, and the pH after dissolution in deionized water lies in the range of 6.7–7.2. Except at the highest drug loading, the folding endurance of the fibers was found to be >20 times. A flavoring agent can easily be incorporated into the formulation. The fiber mats are all seen to disintegrate completely within 0.5 s when added to simulated saliva solution. They release their drug cargo within around 150 s in a dissolution test, and to undergo much more rapid dissolution than is seen for the pure drugs. The data reported herein clearly demonstrate that electrospun PCM/CAF fibers comprise excellent candidates for oral fast-dissolving films, which could be particularly useful for children and patients with swallowing difficulties.
    International Journal of Pharmaceutics 12/2014; 477(1). DOI:10.1016/j.ijpharm.2014.10.036 · 3.79 Impact Factor