Article

CSF Aβ(42) and tau in Parkinson's disease with cognitive impairment.

Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98104, USA.
Movement Disorders (impact factor: 4.51). 11/2010; 25(15):2682-5. DOI:10.1002/mds.23287
Source: PubMed

ABSTRACT We tested the hypothesis that the CSF biomarker signature associated with Alzheimer's disease (AD) is present in a subset of individuals with Parkinson's disease and Dementia (PD-D) or with PD and Cognitive Impairment, Not Dementia (PD-CIND). We quantified CSF Aβ(42), total tau (T-tau), and phospho-tau (P181-tau) using commercially available kits. Samples were from 345 individuals in seven groups (n): Controls ≤50 years (35), Controls >50 years (115), amnestic Mild Cognitive Impairment (aMCI) (24), AD (49), PD (49), PD-CIND (62), and PD-D (11). We observed expected changes in AD or aMCI compared with age-matched or younger controls. CSF Aβ(42) was reduced in PD-CIND (P < 0.05) and PD-D (P < 0.01), whereas average CSF T-tau and P181-tau were unchanged or decreased. One-third of PD-CIND and one-half of PD-D patients had the biomarker signature of AD. Abnormal metabolism of Aβ(42) may be a common feature of PD-CIND and PD-D.

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Keywords

Abnormal metabolism
 
Alzheimer's disease
 
amnestic Mild Cognitive Impairment
 
average CSF T-tau
 
biomarker signature
 
Cognitive Impairment
 
commercially available kits
 
common feature
 
Controls >50 years
 
Controls ≤50 years
 
CSF biomarker signature
 
Parkinson's disease
 
PD
 
PD-CIND
 
PD-D
 
PD-D patients
 
phospho-tau
 
T-tau
 
total tau
 
younger controls