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    • "It was proposed that this interaction represents a safety switch to avoid erroneous TCR/CD3 tyrosine phosphorylation under resting T cell conditions (Kuhns and Davis, 2008). This proposal was subject to discussion following reports that tyrosine phosphorylation of CD3ε cytoplasmic domain did not increase when these basic residues were mutated (Fernandes et al., 2010; Gagnon et al., 2010). A role of PS in generation of signaling protein membrane networks at TCR triggering sites was suggested by reconstructing LATanchored TCR lipid/signaling protein network in vitro: tyrosine phosphorylated LAT was recombinantly expressed as membraneanchored variant in insect cells and inserted into liposomes. "
    Frontiers in Immunology 03/2012; 3:50. DOI:10.3389/fimmu.2012.00050
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    ABSTRACT: This paper presents a low-power design and an area-efficient FPGA implementation of digital channel selection filtering processor for radio receiver. For an homodyne wide-band RF receiver and sigma-delta modulator, two filtering cascade structures composed of 5 stages comb filter, FIR half-band filter and selector filter are compared. Design flow of hardware architecture is presented through digital data format representation and topology of digital operators. Experimental results are given to evaluate performances and complexity of designed FPGA-based implementation.
    Signal Processing and Information Technology, 2004. Proceedings of the Fourth IEEE International Symposium on; 01/2005
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    ABSTRACT: Sub-micron scale signaling domains induced in the plasma membrane of cells are thought to play important roles in signal transduction. In T cells, agonist MHC-peptide complexes induce small diffraction-limited domains enriched in T cell receptor (TCR) and signaling molecules. These microclusters serve as transient platforms for signal initiation and are required for sustained signaling in T cells, although each microcluster functions for only a couple of minutes. How they are formed, and what mechanisms promote and regulate signaling within TCR microclusters is largely unknown, although it is clear that TCR engagement and dynamic reorganization of cortical actin are involved. Here, we review current understanding of signaling within microclusters in T cells, and speculate on how these structures may form, initiate biochemical signals, and serve as sites of both signal integration and amplification, while also facilitating appropriate termination of TCR and related signaling.
    FEBS letters 10/2010; 584(24):4823-31. DOI:10.1016/j.febslet.2010.10.015 · 3.34 Impact Factor
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