The effectiveness of dried cranberries ( Vaccinium macrocarpon ) in men with lower urinary tract symptoms

Department of Urology, University Hospital, Olomouc, Czech Republic.
The British journal of nutrition (Impact Factor: 3.45). 10/2010; 104(8):1181-9. DOI: 10.1017/S0007114510002059
Source: PubMed


Lower urinary tract symptoms (LUTS) are a common condition in older men. The objective of the present study was to evaluate the efficacy and tolerability of cranberry (Vaccinium macrocarpon) powder in men at risk of prostate disease with LUTS, elevated prostate-specific antigen (PSA), negative prostate biopsy and clinically confirmed chronic non-bacterial prostatitis. Forty-two participants received either 1500 mg of the dried powdered cranberries per d for 6 months (cranberry group; n 21) or no cranberry treatment (control group; n 21). Physical examination, International Prostate Symptom Score, quality of life (QoL), five-item version of the International Index of Erectile Function (IIEF-5), basic clinical chemistry parameters, haematology, Se, testosterone, PSA (free and total), C-reactive protein (CRP), antioxidant status, transrectal ultrasound prostate volume, urinary flow rate, ultrasound-estimated post-void residual urine volume at baseline, and at 3 and 6 months, and urine ex vivo anti-adherence activity were determined in all subjects. In contrast to the control group, patients in the cranberry group had statistically significant improvement in International Prostate Symptom Score, QoL, urination parameters including voiding parameters (rate of urine flow, average flow, total volume and post-void residual urine volume), and lower total PSA level on day 180 of the study. There was no influence on blood testosterone or serum CRP levels. There was no statistically significant improvement in the control group. The results of the present trial are the first firm evidence that cranberries may ameliorate LUTS, independent of benign prostatic hyperplasia or C-reactive protein level.

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    • "Further research is necessary to find the active compounds within and their full spectrum of efficacy. C. carandas is a good antimicrobial activity; it has a specific type of flavonoid, proanthocyanidins (PAC); in cranberries it provides urinary tract benefits by interfering with the ability of pathogenic E. coli to cause infections in the urinary tract (Vidlar et al., 2010). Cranberries are thought to provide health benefits due to their flavonoid and phytonutrient content s. "

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    • "For example, significant CRP reductions were observed in subjects consuming diets high in vegetables and fruits (Watzl et al., 2005), red orange juice (Buscemi et al., 2012), orange and blackcurrant juice (Dalgård et al., 2009), mangosteen juice (Udani et al., 2009), or almonds (Rajaram et al., 2010). Conversely, no variations were observed after interventions with a strawberry drink (Basu et al., 2009), carrot juice (Potter et al., 2011), lutein and zeaxanthin-rich food (Graydon et al., 2012), dried cranberries (Vidlar et al., 2010), or cranberry juice (Basu et al., 2011). "
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