Symptom cluster and quality of life: Preliminary evidence in multiple sclerosis

Department of Kinesiology and Community Health, University of Illinois, Urbana, IL, USA.
Journal of Neuroscience Nursing (Impact Factor: 0.82). 08/2010; 42(4):212-6. DOI: 10.1097/JNN.0b013e3181e26c5f
Source: PubMed


This study examined the symptom cluster of fatigue, pain, and depression as a correlate of reduced quality of life (QOL) in individuals with multiple sclerosis (MS). The sample included 291 individuals with a definite diagnosis of MS who were enrolled in a 6-month longitudinal study of physical activity and QOL. The participants completed baseline measures of fatigue, depression, and pain and follow-up measures of QOL. Cluster analysis initially identified three subgroups differing in experiences of fatigue, depression, and pain, and analysis of variance then indicated that the three subgroups differed in QOL. The subgroup with lowest scores on all three symptoms had the highest QOL, whereas the subgroup with the highest scores on the symptoms had the worst QOL. Such findings provide preliminary support for fatigue, pain, and depression as a symptom cluster that correlates with reduced QOL in persons with MS.

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Available from: Edward Mcauley, Feb 16, 2015
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    • "Modifiable lifestyle factors, such as obesity, smoking, risky alcohol consumption and low levels of physical activity were found to have a negative correlation with health-related quality of life [8-10]. Furthermore, several studies concurrently report a negative association between depressive symptoms and chronic pain and SRH [11,12], respectively. In recent years, research has particularly focused on the relationship between different chronic diseases and health-related quality of life. "
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    • "The sub-group with the lowest scores on all three symptoms had the highest QoL, whereas the sub-group with the highest scores on the symptoms had the worst QoL. This observation supports the concept of fatigue, pain and depression as a symptom cluster, which correlates with reduced QoL in patients with MS.[32] Another case-control study in women with relapsing-remitting multiple sclerosis (RRMS) found that pain and pain intensity were significantly more in the RRMS group as compared to controls. However, fatigue and depression intensity was not significantly different between the groups. "
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