Article

Effect of milrinone analogues on intracellular calcium increase in single living H9C2 cardiac cells.

Dipartimento di Scienze Mediche di Base e Applicate, Università degli Studi G. d'Annunzio, via dei Vestini 31, 66100 Chieti, Italy.
European journal of medicinal chemistry (impact factor: 3.27). 11/2010; 45(11):4928-33. DOI:10.1016/j.ejmech.2010.08.001 pp.4928-33
Source: PubMed

ABSTRACT The synthesis of milrinone analogues where the 4-pyridyl moiety was replaced by an ester or amide group is reported. Only amide derivatives are able to support intracellular calcium influx following chemical depolarization with 60 mM KCl in a percentage varying from 20 to 45% of differentiated H9C2 cardiomyocytes. Those cells were differentiated after chronic exposure to 10 nM retinoic acid which induces the expression of voltage-gated calcium channels. Analogues of milrinone containing an ester function did not show significant activity.

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Keywords

10 nM retinoic acid
 
amide derivatives
 
Analogues
 
chemical depolarization
 
induces
 
milrinone analogues
 
percentage varying
 
significant activity
 
voltage-gated calcium channels