Long-term clinical evaluation of asymptomatic subjects positive for circulating Taenia solium antigens

Department of Community Health, Christian Medical College, Vellore, Tamil Nadu, India.
Transactions of the Royal Society of Tropical Medicine and Hygiene (Impact Factor: 1.84). 12/2010; 104(12):809-10. DOI: 10.1016/j.trstmh.2010.07.005
Source: PubMed


Although presence of cysticercal antigens in serum is presumed to indicate active cysticercosis not all positive persons are symptomatic. The significance of a positive antigen test in asymptomatic individuals, in predicting development of symptomatic cysticercosis on long-term follow up, is unknown. Forty two of 48 persons from Vellore district, India who were positive for circulating serum cysticercal antigens were followed up for four to five years. None of them developed clinical evidence of neurocysticercosis or subcutaneous cysts. We conclude that asymptomatic individuals with circulating cysticercal antigens have a low risk of developing symptomatic cysticercosis within four to five years.

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    • "Others have reported that monocytes exposed to helminth antigens have an impaired capability to differentiate into DCs 36-37. In addition, infection with metacestodes is accompanied by antigens in circulation 38-39 that might affect the activity of monocytes. To assess if the differentiation of monocytes into DCs was affected by TcES we added these antigens to our cultures at day 0 and 3. We found that there was no difference in the proportion of CD11c+ cells between cultures that received TcES during their differentiation and the ones that received it only as a final challenge, indicating that TcES did not affect the capability of human monocytes to differentiate into DCs (Fig 1B). "
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