Article

GnRH-agonist induced depressive and anxiety symptoms during in vitro fertilization-embryo transfer cycles.

Department of Psychiatry, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Fertility and sterility (Impact Factor: 4.3). 01/2011; 95(1):307-9. DOI: 10.1016/j.fertnstert.2010.07.1073
Source: PubMed

ABSTRACT To determine whether the use of a GnRH agonist inducing a hypogonadic state during IVF-ET cycles induces negative mood symptoms, we conducted a prospective randomized study in 108 women comparing two different controlled ovarian stimulation protocols. A significant phase effect was observed for depression and anxiety symptoms during IVF-ET cycles reflecting an increase in symptoms between the hypogonadal phase and the peak in gonadotropin stimulation; however, the hypogonadal phase induced by the GnRH agonist was not associated with a significant increase in any of the studied mood parameters.

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