Article

Anti-inflammatory effect of a methanolic extract of leaves of Dregea volubilis.

Pharmacy College, Itaura, Chandeshwar, Azamgarh 276128, Uttar Pradesh, India.
Journal of ethnopharmacology (impact factor: 2.32). 11/2010; 132(2):525-8. DOI:10.1016/j.jep.2010.08.043 pp.525-8
Source: PubMed

ABSTRACT The aim of this study was to establish the anti-inflammatory activity of the methanolic extract of Dregea volubilis leaves (MEDV) with its fractions and to delineate the possible mechanism of action for MEDV.
The anti-inflammatory activities of MEDV along with its petroleum ether and chloroform fractions were evaluated in a carrageenan induced model of acute inflammation. The effect of MEDV on lipopolysaccharide induced production of nitric oxide (NO) in macrophages was also studied.
MEDV (100, 200 and 400 mg/kg body weight) significantly reduced carrageenan induced paw edema; chloroform fraction was most potent (66%, p<0.001). MEDV was non-toxic up to 125 μg/ml in mouse peritoneal macrophages wherein it (0-100 μg/ml) reduced lipopolysaccharide induced NO production.
MEDV possesses significant anti-inflammatory activity. Chloroform fraction of MEDV showed best anti-inflammatory activity.

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Keywords

400 mg/kg body weight
 
acute inflammation
 
anti-inflammatory activities
 
anti-inflammatory activity
 
carrageenan induced model
 
carrageenan induced paw edema
 
Chloroform fraction
 
chloroform fractions
 
Dregea volubilis
 
fractions
 
lipopolysaccharide induced
 
lipopolysaccharide induced production
 
MEDV
 
MEDV possesses significant anti-inflammatory activity
 
nitric oxide
 
petroleum ether
 
possible mechanism