Article

Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe.

State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, East China University of Science and Technology, Shanghai 200237, China.
Chemical Communications (impact factor: 6.17). 10/2010; 46(38):7121-3. DOI:10.1039/c0cc01000f pp.7121-3
Source: PubMed

ABSTRACT A novel NAT2 specific probe has been developed for sensitive detection of the activity of NAT2. Upon NAT2 catalyzed acetylation of the molecule to N-acetyl-amonafide, the ratiometric response of fluorescence with significant changes in wavelength and intensity is observed. Its significant application potential has been successfully demonstrated in cellular systems.

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Keywords

cellular systems
 
NAT2
 
NAT2 catalyzed acetylation
 
novel NAT2 specific probe
 
ratiometric response
 
significant application potential
 
significant changes
 
wavelength
 

Lei Cui