Termination at sTop2

Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Molecular cell (Impact Factor: 14.02). 08/2010; 39(4):487-9. DOI: 10.1016/j.molcel.2010.08.006
Source: PubMed


In this issue of Molecular Cell, Fachinetti et al. provide the first comprehensive map of replication termination sites (TERs) in Saccharomyces cerevisiae (Fachinetti et al., 2010). Strikingly, the majority of TERs are occupied by topoisomerase 2, which shields these regions against genomic instability.

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Available from: Anja Katrin Bielinsky, Mar 20, 2014
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    • " have been shown to be polar in yeast, thus stalling the replisome in one direction (nonpermissive end), while allowing it to pass and continue replication in the other direction (permissive end) (Alver and Bielinsky 2010). Therefore, successful rescue of replication is perhaps dependent on such polarity of adjacent TERs, as well. "
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