Minimal difference between aerobic and progressive resistance exercise on metabolic profile and fitness in older adults with diabetes mellitus: A randomised trial

Department of Physiotherapy, Singapore General Hospital, Singapore.
Journal of physiotherapy (Impact Factor: 2.89). 01/2010; 56(3):163-70. DOI: 10.1016/S1836-9553(10)70021-7
Source: PubMed

ABSTRACT Is progressive resistance training as effective as aerobic training of similar duration in sedentary older adults with diabetes mellitus?
A randomised trial with concealed allocation, assessor blinding and intention-to-treat analysis.
Sixty people with Type 2 diabetes mellitus with glycosylated haemoglobin (HbA1c) between 8% and 10% in the past month.
One group undertook progressive resistance exercise and the other group undertook aerobic exercise. Both groups completed 18 sessions over 8 weeks. In each session, the progressive resistance exercise group did nine resistive exercises while the aerobic exercise group did 50 minutes of aerobic exercise.
HbA1c, blood glucose, lipid profile (total, high- and low-density cholesterol and triglycerides), weight, body mass index, body fat, waist circumference, waist:hip ratio, blood pressure, and peak oxygen consumption.
Forty-nine (82%) participants completed the intervention. HbA1c reduced by a similar amount in both groups (MD 0.1%, 95% CI -0.3 to 0.5). However, significant between-group differences occurred in change in waist circumference in favour of progressive resistance exercise (MD -1.8 cm, 95% CI -0.5 to -3.1), and in change in peak oxygen consumption in favour of aerobic exercise (MD 5.2 ml/kg, 95% CI 0.0 to 10.4).
Progressive resistance exercise has similar effects to aerobic exercise and therefore offers a useful alternative for patients unable to participate in aerobic exercise.

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Available from: Rahul Malhotra, Aug 03, 2015
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    • "26 30 57 0 3 R Tv s AET 48 h after last exercise tests AET: ↓ HbA 1c ; ↑ V ⋅ O 2max RT: ↓ WHR, HbA 1c Ng et al 2010 [38] "
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    ABSTRACT: Aims/hypothesis This study aimed to systematically review randomised controlled trials comparing the effects of aerobic exercise training (AET), resistance training (RT) and combined training (CT) on glycaemic control and blood lipids in patients with type 2 diabetes mellitus. Methods Searches were performed in MEDLINE, EMBASE and the Cochrane Library. Inclusion criteria were: type 2 diabetes mellitus, adult, supervised training and a minimum intervention period of 8 weeks. Pooled effects were calculated by fixed/random effect pairwise and Bayesian fixed/random effects network meta-analyses. Results A total of 14 trials enrolling 915 participants were included. AET was more effective than RT in improving HbA(1c) levels (mean difference [MD] -0.20% [-2.2 mmol/mol]; 95% CI -0.32, -0.08; p=0.0007, 10 trials/515 participants) and fasting glucose (MD -0.9 mmol/l; 95% CI -1.71, -0.09; p=0.03, 8 trials/245 participants). Compared with AET, CT resulted in a significantly more pronounced reduction in HbA(1c) (MD -0.17% [-1.87 mmol/mol]; 95% CI -0.31, -0.03; p=0.02, 9 trials/493 participants). Compared with RT, the MD of the change in HbA(1c) (MD -0.62%, [-6.82 mmol/mol]; 95% CI -0.95, -0.30; p=0.0002, 5 trials/362 participants], fasting glucose (MD -1.99 mmol/l; 95% CI -3.07, -0.90; p=0.0003, 3 trials/99 participants) and triacylglycerols (MD -0.28 mmol/l; 95% CI -0.46, -0.10; p=0.003, 4 trials/213 participants) were all in favour of CT. The exclusion of trials with a high risk of bias yielded only non-significant results. Conclusions/interpretation The present data suggest that CT might be the most efficacious exercise modality to improve glycaemic control and blood lipids. Interpretation with respect to clinical relevance is limited by the low quality of the studies included and the limited information on the clinically important outcomes or adverse effects of exercise.
    Diabetologia 07/2014; 57(9). DOI:10.1007/s00125-014-3303-z · 6.88 Impact Factor
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