Article

TFInfer: a tool for probabilistic inference of transcription factor activities.

School of Informatics, University of Edinburgh, 10 Crichton Street, Edinburgh EH8 9AB, UK.
Bioinformatics (impact factor: 5.47). 10/2010; 26(20):2635-6. DOI:10.1093/bioinformatics/btq469 pp.2635-6
Source: PubMed

ABSTRACT TFInfer is a novel open access, standalone tool for genome-wide inference of transcription factor activities from gene expression data. Based on an earlier MATLAB version, the software has now been extended in a number of ways. It has been significantly optimised in terms of performance, and it was given novel functionality, by allowing the user to model both time series and data from multiple independent conditions. With a full documentation and intuitive graphical user interface, together with an in-built data base of yeast and Escherichia coli transcription factors, the software does not require any mathematical or computational expertise to be used effectively.
http://homepages.inf.ed.ac.uk/gsanguin/TFInfer.html
gsanguin@staffmail.ed.ac.uk
Supplementary data are available at Bioinformatics online.

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    PLoS ONE 01/2011; 6(9):e25501. · 4.09 Impact Factor
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Keywords

Bioinformatics online
 
full documentation
 
gene expression data
 
genome-wide inference
 
in-built data base
 
intuitive graphical user interface
 
MATLAB version
 
multiple independent conditions
 
novel open access
 
transcription factor activities
 
yeast