Article

Partial status epilepticus induced by hypocupremia in a patient with Wilson's disease.

Cerrahpasa Faculty of Medicine, Department of Neurology, Istanbul University, Istanbul, Turkey.
Seizure (impact factor: 1.8). 11/2010; 19(9):602-4. DOI:10.1016/j.seizure.2010.07.018 pp.602-4
Source: PubMed

ABSTRACT Although seizures are rarely encountered in Wilson's disease (WD), seizures related to hypocupremia have not been reported before. We report a patient presenting with partial status epilepticus who was on strict low-copper diet and chelating therapy for WD. Despite other rare causes of seizures in WD including penicillamine-induced pyridoxine deficiency, cerebral copper deposition and metabolic encephalopathy, the most probable cause of resistant status epilepticus in this patient was found as hypocupremia from overzealous treatment. This case exemplifies that hypocupremic states should be kept in mind as a risk factor for resistant seizures.

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Keywords

cerebral copper deposition
 
chelating therapy
 
hypocupremic states
 
metabolic encephalopathy
 
overzealous treatment
 
partial status epilepticus
 
penicillamine-induced pyridoxine deficiency
 
probable cause
 
risk factor
 
strict low-copper diet
 
WD
 
Wilson's disease