Prevention: Reducing the risk of CVD in patients with periodontitis
ABSTRACT The association between periodontitis and other chronic diseases, such as cardiovascular disease (CVD) and type 2 diabetes mellitus, could be related to systemic inflammation initiated by a local inflammatory challenge. Oliveira et al. have added lack of oral hygiene, and its link with systemic inflammation, to the spectrum of risk factors for CVD.
- SourceAvailable from: Ahmed Hashim[Show abstract] [Hide abstract]
ABSTRACT: Porphyromonas gingivalis is a low-abundance oral anaerobic bacterium implicated in periodontitis, a polymicrobial inflammatory disease, and the associated systemic conditions. However, the mechanism by which P. gingivalis contributes to inflammation and disease has remained elusive. Here we show that P. gingivalis, at very low colonization levels, triggers changes to the amount and composition of the oral commensal microbiota leading to inflammatory periodontal bone loss. The commensal microbiota and complement were both required for P. gingivalis-induced bone loss, as germ-free mice or conventionally raised C3a and C5a receptor-deficient mice did not develop bone loss after inoculation with P. gingivalis. These findings demonstrate that a single, low-abundance species can disrupt host-microbial homeostasis to cause inflammatory disease. The identification and targeting of similar low-abundance pathogens with community-wide impact may be important for treating inflammatory diseases of polymicrobial etiology.Cell host & microbe 11/2011; 10(5):497-506. DOI:10.1016/j.chom.2011.10.006 · 12.19 Impact Factor
Conference Paper: Optimal posture control for object on active vision robot[Show abstract] [Hide abstract]
ABSTRACT: The paper describes way of determining the optimal posture of active vision robot (AVRobot) for recognizing unidentified objects. In the object recognition with visual information by the AVRobot, it is required to measure the accurate positions of feature points of a target object. For the precise measurement, it is preferable, for example, that several feature points exist in a captured image for calculation of relative positions and distances among them and that the position of feature point on the image moves boldly in small motion of the camera attached on the robot. In this paper, the motion control law based on visual servoing and posture design technique with -space vector is proposed so as to satisfy such requirements. The control law simultaneously achieves two control requirement in our approach; the first one is to make the position of primary feature point of the target locate center of the image, and the second to induce the camera position where let the image transition sensitive to the infinitesimal change of the camera motion referring the positions of the secondary features, so as to suppress the measurement errors of the feature positions.Control Applications, 2004. Proceedings of the 2004 IEEE International Conference on; 10/2004
- The American journal of medicine 11/2011; 124(11):997-9. DOI:10.1016/j.amjmed.2011.04.035 · 5.30 Impact Factor