Article

Tissue-specific Functions in the Fatty Acid-binding Protein Family

Department of Nutritional Sciences and the Rutgers Center for Lipid Research, Rutgers University, New Brunswick, New Jersey 08901, USA.
Journal of Biological Chemistry (Impact Factor: 4.57). 10/2010; 285(43):32679-83. DOI: 10.1074/jbc.R110.135210
Source: PubMed

ABSTRACT The intracellular fatty acid-binding proteins (FABPs) are abundantly expressed in almost all tissues. They exhibit high affinity binding of a single long-chain fatty acid, with the exception of liver FABP, which binds two fatty acids or other hydrophobic molecules. FABPs have highly similar tertiary structures consisting of a 10-stranded antiparallel β-barrel and an N-terminal helix-turn-helix motif. Research emerging in the last decade has suggested that FABPs have tissue-specific functions that reflect tissue-specific aspects of lipid and fatty acid metabolism. Proposed roles for FABPs include assimilation of dietary lipids in the intestine, targeting of liver lipids to catabolic and anabolic pathways, regulation of lipid storage and lipid-mediated gene expression in adipose tissue and macrophages, fatty acid targeting to β-oxidation pathways in muscle, and maintenance of phospholipid membranes in neural tissues. The regulation of these diverse processes is accompanied by the expression of different and sometimes multiple FABPs in these tissues and may be driven by protein-protein and protein-membrane interactions.

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    • "Moreover, the expression profile of FABPs in cerebral cortex confirms that FABP5 and 7 were expressed in the brain mainly at the late embryonic stage [23] with an abundance level 10-times higher than that of other fatty acid transport proteins. This superiority , which persists until day 14 of lactation, is supposed to be required during brain development for AA and DHA channelling for phospholipid and membrane synthesis during proliferation/ differentiation of stem cells and neurite outgrowth [23] [49]. "
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