Article

Candida-associated denture stomatitis

SUN-Dipartimento di Discipline Odontostomatologiche, Ortodontiche e Chirurgiche, Università degli Studi di Foggia, Foggia, Italy.
Medicina oral, patologia oral y cirugia bucal (Impact Factor: 1.1). 03/2011; 16(2):e139-43. DOI: 10.4317/medoral.16.e139
Source: PubMed

ABSTRACT Candida albicans is a dimorphic yeast strongly gram positive able to live as normal commensal organism in the oral cavity of healthy people. It is the yeast more frequently isolated in the oral cavity. Under local and systemic factors related to the host conditions, it becomes virulent and responsible of oral diseases known as oral candidiasis. It has been shown that the presence of denture is a predisposing factor to the onset of pathologies related to C. albicans. Clinical studies have shown that C. albicans is not only able to adhere to the mucous surfaces, but also to stick to the acrylic resins of the dental prostheses. Both the plaque accumulated on the denture and the poor oral hygiene contribute to the virulence of Candida, offering the clinical picture of Candida-associated denture stomatitis. The therapeutic strategies currently adopted in the clinical practice to overcome these fungal infections provide for the use of topical and/or systemic antifungal and topical antiseptics and disinfectants, the irradiation with microwaves and the accurate mechanical removal of the bacterial plaque from the denture surfaces and from the underlying mucosa. A correct oral hygiene is important for the control of the bacterial biofilm present on the denture and on the oral mucosa and it is the fundamental base for the prophylaxis and the therapy of the Candida-associated denture stomatitis.

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    • "Recently, rate of systemic fungal infection caused by Candida species has risen up dramatically due to an increase in immunocompromised hosts (AIDS), hematologic disorders, malignancies and biologic resistance to common antibiotics. Therapeutic strategies against fungal infections are based on topical and systemic antifungal agents [24]. Antifungal drugs are cytotoxic and susceptibility of some Candida species to these drugs is reducing. "
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    ABSTRACT: Candida species are opportunistic fungi, among which, Candida albicans is the most important species responsible for infections in immunocompromised patients with invasive fungal disease. Resistance of Candida species to antifungal drugs has led scientists to pay more attention to traditional medicine herbs. Due to the limitations in the treatment of fungal diseases such as shortages, high prices, antifungal side effects and drug resistance or reduced susceptibility to fungal drugs we decided to study the antifungal effects of herbal extracts of Syzygium aromaticum and Punica granatum.
    Journal de Mycologie Médicale/Journal of Medical Mycology 10/2014; 24(4). DOI:10.1016/j.mycmed.2014.07.001 · 0.40 Impact Factor
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    • "The association of these procedures with topic antifungal therapy showed good results in the reduction of the palatal mucosa inflammation and decreasing of yeast number of Candida spp. in the palate and in denture fitting [2] [8] [9]. The most common synthetic drugs used are imidazole related compounds such as miconazole, polyenic derivatives such as nystatin and others [2] [3] [5] [10]. Miconazole is an antifungal for topical oral administration and has been showing a good effect in therapeutic or prophylactic treatment of Candida-associated denture stomatitis, reducing erythema [2] [11], and decreasing colonies of Candida spp. "
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    ABSTRACT: Aim. To evaluate the efficacy of Brazilian green propolis in comparison to miconazole gel in the treatment of Candida-associated denture stomatitis. Methods. Forty-five denture stomatitis patients, with palatal mucosa erythema levels classified according to Newtons's criteria and with positive culture to Candida spp., were randomly divided into three treatment groups: 15 received miconazole gel 2%, 15 received propolis gel 2,5%, and 15 received propolis 24% for mouthwash. After four daily use lasting two weeks, they were reexamined for the denture stomatitis degree and for a second culture of Candida. The Wilcoxon's test was applied to compare the results of clinical classification of the denture stomatitis and the Candida spp. colonies numbers, before and after each treatment. The Kruskall-Wallis's test was used to compare efficacy among the three treatment groups. Results. There were a significant reduction or complete remission of denture stomatitis (P < 0.05) and a significant decrease of Candida colonies for the three groups (P < 0.05). There was no difference in the efficacy among the treatment groups (P > 0.05). Conclusion. Brazilian green propolis has a similar effect as miconazole in the treatment of Candida-associated denture stomatitis being an alternative in the therapeutics of this condition.
    Evidence-based Complementary and Alternative Medicine 05/2013; 2013(3):947980. DOI:10.1155/2013/947980 · 1.88 Impact Factor
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    • "Most infections are, however, super�cial, a�ecting the moist mucosal surfaces of the oral cavity and vagina in debilitated individuals. e occurrence of super�cial oral candidosis may arise from a multitude of factors including local immune suppression, reduced salivary �ow, poor oral hygiene, smoking, denture wearing, hormonal imbalances, and nutritional de�ciencies [4] [5] [6] [7] [8]. Furthermore, receipt of broad-spectrum antibiotics has also been implicated with subsequent mucosal and systemic candidal infection [9]. "
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    ABSTRACT: Human infections involving yeast of the genus Candida often occur in the presence of bacteria, and, as such, it is important to understand how these bacteria influence innate host immunity towards Candida. Dectin-1 is a cell receptor of macrophages for Candida albicans recognition. The aim of this study was to examine dectin-1 expression by monocytes after stimulation with bacterial lipopolysaccharide (LPS), followed by heat-killed C. albicans (HKC). Freshly isolated human peripheral blood monocytes (PBMCs) and human monocytes cell line (THP-1) cells expressed low levels of dectin-1. Stimulation with LPS and GM-CSF/IL-4 was found to increase dectin-1 expression in both CD14(+) human PBMC and THP-1 cells. Enhanced dectin-1 expression resulted in increased phagocytosis of Candida. When THP-1 cells were challenged only with HKC, detectable levels of IL-23 were not evident. However, challenge by LPS followed by varying concentrations of HKC resulted in increased IL-23 expression by THP-1 cells in HKC dose-dependent manner. Increased expression of IL-17 by PBMC also occurred after stimulation with Candida and LPS. In conclusion, bacterial LPS induces an enhanced immune response to Candida by immune cells, and this occurs through increasing dectin-1 expression.
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