Cytokinesis through biochemical-mechanical feedback loops.

Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Seminars in Cell and Developmental Biology (Impact Factor: 6.2). 12/2010; 21(9):866-73. DOI: 10.1016/j.semcdb.2010.08.003
Source: PubMed

ABSTRACT Cytokinesis is emerging as a control system defined by interacting biochemical and mechanical modules, which form a system of feedback loops. This integrated system accounts for the regulation and kinetics of cytokinesis furrowing and demonstrates that cytokinesis is a whole-cell process in which the global and equatorial cortices and cytoplasm are active players in the system. Though originally defined in Dictyostelium, features of the control system are recognizable in other organisms, suggesting a universal mechanism for cytokinesis regulation and contractility.

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