Proliferative and protective effects of SurR9-C84A on differentiated neural cells

Institute of Biotechnology (BioDeakin), Institute for Technology Research and Innovation (ITRI), Deakin University, Australia.
Journal of neuroimmunology (Impact Factor: 2.47). 10/2010; 227(1-2):120-32. DOI: 10.1016/j.jneuroim.2010.06.024
Source: PubMed


Targeting survivin has the ability to inhibit apoptosis and regulate mitosis for the protection of neuronal cells, and it offers several advantages for neuronal repair and protection. We found that the BIR motif mutant of survivin (SurR9-C84A) can bind to microtubules and regulate their stability, induce cell division, increase proliferation and activate the expression of cell cycle and neuronal markers in differentiated SK-N-SH and HCN-2 neurons. We further showed the protective effects of SurR9-C84A against post differentiation retinoic acid induced neurotoxicity. These abilities of SurR9-C84A offer a great potential for future neuronal repair therapy.

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    • "Likewise, we have identified that the mutant form of survivin, SurR9-C84A (baculovirus inhibitor of apoptosis repeat motif) has solid neuroprotective activity when tested in SK-N-SH cells subjected to oxidative stress induced by hydrogen peroxide.165 Following this, we also identified the potential of SurR9-C84A in stimulating neuronal proliferation, survival, and expression of neuronal markers when tested in SK-N-SH and HCN-2 cell lines.166 Further to this, we also noted the neuroprotective and mitogenic effects of BARF1 epitopes of Epstein-Barr virus.167 "
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    • "In studying the neuroproliferative and protective effects of SurR9-84A, an IAP repeat mutant of survivin, we found a strong neuroprotective effect against the release of soluble inflammatory mediators from activated T-cells and hydrogen peroxide-mediated oxidative stress. These effects were due to the role of SurR9-84A in altering mitochondrial permeability, balancing calcium homeostasis and inhibiting apoptosis (Baratchi et al., 2010). "
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