The inhibitory effects of Gelam honey and its extracts on nitric oxide and prostaglandin E(2) in inflammatory tissues.

Department of Anesthesiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Fitoterapia (Impact Factor: 2.23). 12/2010; 81(8):1196-201. DOI: 10.1016/j.fitote.2010.07.024
Source: PubMed

ABSTRACT We investigated the effects of honey and its methanol and ethyl acetate extracts on inflammation in animal models. Rats' paws were induced with carrageenan in the non-immune inflammatory and nociceptive model, and lipopolysaccharide (LPS) in the immune inflammatory model. Honey and its extracts were able to inhibit edema and pain in inflammatory tissues as well as showing potent inhibitory activities against NO and PGE(2) in both models. The decrease in edema and pain correlates with the inhibition of NO and PGE(2). Phenolic compounds have been implicated in the inhibitory activities. Honey is potentially useful in the treatment of inflammatory conditions.

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    ABSTRACT: Introduction Exposure to stress during pregnancy has been shown to have adverse effects on pregnancy outcomes such as low birth weight, spontaneous abortion and premature delivery. Honey has been shown to improve testicular function in rats exposed to cigarette smoke. The aim of this study was to determine the effects of honey on corticosterone level, adrenal gland histomorphometry and pregnancy outcomes in pregnant rats subjected to restraint stress. Materials and methods Rat dams were divided into four groups (n = 10/group) i.e. control, honey, stress and honey plus stress (honey + stress) groups. Rats from honey and honey + stress groups received Tualang honey (1.2 g/kg body weight/day) orally by gavage from Day 0 of pregnancy until delivery. Rats from stress and honey + stress groups were subjected to stress by repeated restraining (three times/day) from Day 11 of pregnancy until delivery. Following delivery, pregnancy outcomes were assessed and dams were euthanized at postnatal Day 21 for assessments on serum corticosterone level, adrenal gland histology and rate of resorption. Results Rats from stress group had significantly higher corticosterone level, zona fasciculata thickness and duration of pregnancy as well as decreased litter size when compared with control and honey groups. These parameters were significantly improved in rats receiving honey (honey + stress group). Conclusion Supplementation of honey has a protective effect against increased corticosterone level and zona fasciculata thickness as well as impaired pregnancy outcomes in rats subjected to restraint stress.
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May 27, 2014