Article

Cell cycle: deconstructing tension.

Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, Milan, Italy.
Current biology: CB (impact factor: 10.99). 08/2010; 20(15):R634-7. DOI:10.1016/j.cub.2010.06.014 pp.R634-7
Source: PubMed

ABSTRACT Prior to anaphase, sister chromatids must be attached to microtubules and under tension, a condition that satisfies the spindle checkpoint. Removal of sister chromatid cohesion is predicted to cause a fall in tension. Two studies shed light on how cells avoid re-activation of the spindle checkpoint when cohesion is lost.

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Keywords

re-activation
 
sister chromatid cohesion
 
sister chromatids
 
spindle checkpoint
 

Andrea Musacchio