Azzoli CG, Baker S Jr, Temin S, et al. American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer. J Clin Oncol. 27:(36)6251-6266

Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Zhongguo fei ai za zhi = Chinese journal of lung cancer 03/2010; 13(3):171-89. DOI: 10.3779/j.issn.1009-3419.2010.03.15
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ABSTRACT The purpose of this article is to provide updated recommendations for the treatment of patients with stage IV non-small-cell lung cancer. A literature search identified relevant randomized trials published since 2002. The scope of the guideline was narrowed to chemotherapy and biologic therapy. An Update Committee reviewed the literature and made updated recommendations. One hundred sixty-two publications met the inclusion criteria. Recommendations were based on treatment strategies that improve overall survival. Treatments that improve only progression-free survival prompted scrutiny of toxicity and quality of life. For first-line therapy in patients with performance status of 0 or 1, a platinum-based two-drug combination of cytotoxic drugs is recommended. Nonplatinum cytotoxic doublets are acceptable for patients with contraindications to platinum therapy. For patients with performance status of 2, a single cytotoxic drug is sufficient. Stop first-line cytotoxic chemotherapy at disease progression or after four cycles in patients who are not responding to treatment. Stop two-drug cytotoxic chemotherapy at six cycles even in patients who are responding to therapy. The first-line use of gefitinib may be recommended for patients with known epidermal growth factor receptor (EGFR) mutation; for negative or unknown EGFR mutation status, cytotoxic chemotherapy is preferred. Bevacizumab is recommended with carboplatin-paclitaxel, except for patients with certain clinical characteristics. Cetuximab is recommended with cisplatin-vinorelbine for patients with EGFR-positive tumors by immunohistochemistry. Docetaxel, erlotinib, gefitinib, or pemetrexed is recommended as second-line therapy. Erlotinib is recommended as third-line therapy for patients who have not received prior erlotinib or gefitinib. Data are insufficient to recommend the routine third-line use of cytotoxic drugs. Data are insufficient to recommend routine use of molecular markers to select chemotherapy.

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    • "Among all lung cancer cases, 84% are classified as non-small cell lung cancer (NSCLC) and 15% as small-cell lung cancer for the purpose of treatment. The microtubule stabilization agent paclitaxel (PX) is used either as a monotherapy or in combination with carboplatin for the treatment of NSCLC.2 "
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    • "Several phase III studies have demonstrated the clinical efficacy of the epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) gefitinib and erlotinib compared with chemotherapy against advanced NSCLC when used as first-line treatment for patients whose tumors harbor activating EGFR mutations.3–8 Several clinical practice guidelines now recommend EGFR mutation testing before initiation of first-line therapy for advanced NSCLC.9–11 "
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    • "To gain insight into the source and the potential mechanism of cisplatin-induced generation of ROS in human cells, we analyzed the temporal nature of this process. We used the non-small cell lung cancer cell line A549, as cisplatin-based chemotherapy is a standard of care for this type of tumor [37]. In order to determine the role of mitochondria in cisplatin-induced ROS generation we utilized the prostate cancer cell lines DU145 and its isogenic ρ0 derivative (DU145ρ°; ρ0 status was validated as described in Figure S1). "
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    PLoS ONE 11/2013; 8(11):e81162. DOI:10.1371/journal.pone.0081162 · 3.23 Impact Factor
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