Immunoregulatory roles for fc receptor-like molecules.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Current topics in microbiology and immunology (Impact Factor: 3.47). 01/2011; 350:89-104. DOI: 10.1007/82_2010_88
Source: PubMed

ABSTRACT Fc receptor-like (FCRL) molecules comprise a family of imunoregulatory transmembrane proteins that are preferentially, but not exclusively expressed on B lineage cells. A strong regulatory potential on B cell activation has been characterized for the different FCRL proteins, but their biological roles are just beginning to be elucidated. We review recent advances in the understanding of FCRL1-6 expression and function, and indicate their potential roles in the pathogenesis of immunodeficiencies, lymphoid malignancies and autoimmune diseases.

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