Prefrontal-striatl pathway underlies cognitive regulation of craving

Division of Substance Abuse, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA.
Proceedings of the National Academy of Sciences (Impact Factor: 9.67). 08/2010; 107(33):14811-6. DOI: 10.1073/pnas.1007779107
Source: PubMed


The ability to control craving for substances that offer immediate rewards but whose long-term consumption may pose serious risks lies at the root of substance use disorders and is critical for mental and physical health. Despite its importance, the neural systems supporting this ability remain unclear. Here, we investigated this issue using functional imaging to examine neural activity in cigarette smokers, the most prevalent substance-dependent population in the United States, as they used cognitive strategies to regulate craving for cigarettes and food. We found that the cognitive down-regulation of craving was associated with (i) activity in regions previously associated with regulating emotion in particular and cognitive control in general, including dorsomedial, dorsolateral, and ventrolateral prefrontal cortices, and (ii) decreased activity in regions previously associated with craving, including the ventral striatum, subgenual cingulate, amygdala, and ventral tegmental area. Decreases in craving correlated with decreases in ventral striatum activity and increases in dorsolateral prefrontal cortex activity, with ventral striatal activity fully mediating the relationship between lateral prefrontal cortex and reported craving. These results provide insight into the mechanisms that enable cognitive strategies to effectively regulate craving, suggesting that it involves neural dynamics parallel to those involved in regulating other emotions. In so doing, this study provides a methodological tool and conceptual foundation for studying this ability across substance using populations and developing more effective treatments for substance use disorders.

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    • "pact of reappraisal on emotional valence and arousal , is related to cigarette craving in nicotine addicts . Previous studies have indicated that cigarette craving triggers cigarette smoking ( Kober et al . , 2010a ) and cognitive emotion regulation involves neural dynamics parallel to craving regulation ( i . e . , prefrontal - striatal pathway ; Kober et al . , 2010b ; Tabibnia et al . , 2014 ) . In line with this , previous studies have shown that more negative emotions are associated with more cigarette craving ( Juliano and Brandon , 2002 ; Baker et al . , 2004 ; Shiffman and Waters , 2004 ; Conklin and Perkins , 2005 ; Bradley et al . , 2007 ; Battista et al . , 2008 ; Nakajima and Al ' abs"
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