Androgens stimulate telomerase expression, activity and phosphorylation in ovarian adenocarcinoma cells

Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, 1417613151 Tehran, Iran.
Molecular and Cellular Endocrinology (Impact Factor: 4.41). 12/2010; 330(1-2):10-6. DOI: 10.1016/j.mce.2010.07.021
Source: PubMed


Androgens have been implicated in increasing ovarian cancer risk. Most ovarian cancer cells have high telomerase activity which is effective in inducing ovarian carcinogenesis. The purpose of this study was to investigate the effects of testosterone and androstenedione on the viability of an ovarian adenocarcinoma cell line, the activity and expression of telomerase, and the phosphorylation status of its catalytic subunit in these cells. Results showed that androgens significantly increased the viability of ovarian cancer cells and that these hormones induced the expression, activity and phosphorylation of telomerase. This upregulation was blocked by phosphatidylinositol 3-kinase pathway inhibitors. These findings might have implications for understanding the role of androgens in ovarian carcinogenesis.

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    • "Shi et al. (2011) examined the role of DHT, testosterone, and dehydroepiandrosterone (DHEA) in breast and ovarian cancer cell lines, and found that DHT but not the other androgens induced the degradation of the tumor suppressor p27 in both cell lines. Furthermore, in ovarian carcinoma cell lines, testosterone and androstenedione were found to increase cell viability, and induce telomerase activity which was blocked by PI3K inhibitors (Nourbakhsh et al., 2010). Sheach et al. (2009) found that the ovarian cancer cell lines OVCAR3 and OSEC2 expressed the androgen receptor, and treatment with androgen upregulated 121 genes, including G-protein-related genes Rab25 and Rab35. "

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