Soluble Endoglin for the Prediction of Preeclampsia in a High Risk Cohort
Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA. Hypertension in Pregnancy
(Impact Factor: 1.41).
08/2010; 29(3):330-41. DOI: 10.3109/10641950902968684
To evaluate soluble endoglin (sEng) and the soluble fms-like tyrosine kinase 1 (sFlt1) to placental growth factor (PlGF) ratio for the prediction of preeclampsia in high-risk women, and to evaluate differences in sEng between women with high-risk singleton and multiple gestation pregnancies.
We collected serial serum specimens from 119 women at high preeclampsia risk. sEng, sFlt1 and PlGF were measured by ELISA.
Among subjects who did not develop preeclampsia, mean serum sEng was significantly higher in those with multiple gestation pregnancies vs. high-risk singletons. Among women with singleton gestations, mean serum sEng was higher in subjects who developed early-onset (<34 weeks) and late-onset (>or= 34 weeks) preeclampsia, as compared with subjects without preeclampsia, from 22 weeks and 28 weeks gestation onward, respectively. The within-woman rate of change of sEng was also higher in women who later developed preeclampsia.
sEng is higher in women with multiple gestations vs. high-risk singleton pregnancies. In high-risk women, serum sEng is increased prior to preeclampsia onset.
Available from: Harapan Harapan, MD
- "In the second stage, the ischemic and hypoxic placenta releases anti-angiogenic factors such as soluble Fms-like tyrosine kinase-1 (sFlt-1), soluble endoglin (sEng), prostaglandins and cytokines into the maternal circulation and dysregulates the production of pro-angiogenic factors including vascular endothelial growth factor (VEGF), placental growth factor (PlGF), fibroblast growth factor (FGF), transforming growth factor-B (TGF-B) and insulin-like growth factor I (IGF-I)    . It is clear that the levels of sFlt1, sEng and other anti-angiogenic factors are increased and the concentrations of VEGF, PlGF and other pro-angiogenic factors are decreased in preeclampsia              . These changes induce systemic endothelial dysfunction and inflammatory response leading to elevated systemic vascular resistance, vasoconstriction, and activation of the coagulation cascade . "
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ABSTRACT: Background: In pre-clinical stage of preeclampsia, placental angiogenesis is impaired leading to hypoxic placenta and dysregulation of pro- and anti-angiogenetic factors. As a consequence, these cause elevated systemic vascular resistance, vasoconstriction and hypertension in clinical stage of preeclampsia. Dysregulation of microRNAs (miRNAs) has been observed among preeclampsia patients and they are involved in several aspects of preeclampsia pathogenesis. Aims: To evaluate the roles of miRNAs in angiogenesis and vascular pressure in preeclampsia. Material and methods: Articles from MEDLINE database (between 2007 and February 2015) were searched by using the combination of Medical Subject Headings (MeSH terms) "preeclampsia", "pre-eclampsia", "miRNA" and "microRNA". All sources of miRNAs, all types of preeclampsia and all techniques used in measuring miRNAs were included. Furthermore, bibliographies of the articles were also retrieved for further relevant references. Results: Data reveal that miRNAs interfere with angiogenesis during early pregnancy by dysregulating pro-angiogenic factors (such as placental growth factor, vascular endothelial growth factor, fibroblast growth factor, transforming growth factor and insulin-like growth factor) and their receptors including Fms-like tyrosine kinase-1 and fibroblast growth factor receptor 1. In addition, miRNAs are also involved on high vascular pressure during preeclampsia by targeting several vasodilators such as prostacyclin, 17β-estradiol, hydrogen sulfide and nitric oxide, and inducing the production of angiotensin type I receptor agonistic autoantibodies. Conclusion: Data confirm that miRNAs are involved in pathobiology of preeclampsia including interference with angiogenesis during pre-clinical stage and induction of vascular resistance and vasoconstriction in clinical stage.
Egyptian Journal of Medical Human Genetics 04/2015; 183(4). DOI:10.1016/j.ejmhg.2015.03.006
Available from: Rocco C Venuto
- "Increased maternal serum levels of sEng were detected prior to preeclampsia onset in healthy, nulliparous women [74, 75] as well as in high-risk pregnant population . "
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ABSTRACT: Hypertension is the most common medical disorder encountered during pregnancy. Hypertensive disorders are one of the major causes of pregnancy-related maternal deaths in the United States. We will present a comprehensive update of the literature pertinent to hypertension in pregnancy. The paper begins by defining and classifying hypertensive disorders in pregnancy. The normal vascular and renal physiological changes which occur during pregnancy are detailed. We will summarize the intriguing aspects of pathophysiology of preeclampsia, emphasizing on recent advances in this field. The existing diagnostic tools and the tests which have been proposed for screening preeclampsia are comprehensively described. We also highlight the short- and long-term implications of preeclampsia. Finally, we review the current management guidelines, goals of treatment and describe the potential risks and benefits associated with various antihypertensive drug classes. Preeclampsia still remains an enigma, and the present management focuses on monitoring and treatment of its manifestations. We are hopeful that this in depth critique will stimulate the blossoming research in the field and assist practitioners to identify women at risk and more effectively treat affected individuals.
Journal of pregnancy 05/2012; 2012(4):105918. DOI:10.1155/2012/105918
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ABSTRACT: A model-based image understanding and spatial reasoning system (SRS) has been integrated with a robot planner to provide a testbed for autonomously sensing and responding to complex but well-structured environments. The entire system operates in such a way that the robot planner requests state information for entities on a task panel from the SRS. State information may consist of the location or orientation of a latch or door on the panel or it may reflect a particular function, such as whether a latch is open or closed. Examples which illustrate the operation of the entire system with actual robotic and vision hardware are provided. The advantages and disadvantages of active/passive markers and teleoperation within the context of the integrated system are also discussed
Robotics and Automation, 1989. Proceedings., 1989 IEEE International Conference on; 06/1989
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