Inflammasomes and anti-viral immunity

Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.
Journal of Clinical Immunology (Impact Factor: 2.65). 09/2010; 30(5):632-7. DOI: 10.1007/s10875-010-9431-4
Source: PubMed

ABSTRACT Type I Interferons are the hallmark cytokines deployed during infection to combat invading viruses. However, inflammatory cytokines such as Interleukin (IL)-1beta and IL-18 also play important roles in anti-viral defenses. The activity of IL-1beta and IL18 are regulated at the level of expression, processing, and secretion. Several classes of innate immune receptors control the expression of these cytokines, which must then be proteolytically processed via caspase-1. In this review, we provide an overview of how caspase-1-activating inflammasomes participate during viral infections and their role in regulating anti-viral immunity.

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    • "importance of IL-1b (and IL-18) in anti-viral defenses that are supported by the enhanced susceptibility of mice lacking the cytokine receptors to virus infection [38]. Therefore, during salmon IPNV infection, lack of induction of IL-1b and IL-8 expression in the immune organs may actually weaken anti-viral activity and impair resolution of the infection. "
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